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Titolo:
Differential postsynaptic distribution of GluRs 1-4 on cartwheel and octopus cell somata in the gerbil cochlear nucleus
Autore:
Schwartz, IR; Keh, A; Eager, PR;
Indirizzi:
Yale Univ, Sch Med, Otolaryngol Sect, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 tolaryngol Sect, New Haven, CT 06520 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 147, anno: 2000,
pagine: 70 - 76
SICI:
0378-5955(200009)147:1-2<70:DPDOG1>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-RECEPTOR SUBUNITS; CALCIUM-BINDING PROTEINS; AUDITORY BRAIN-STEM; AMPA RECEPTORS; CA2+ PERMEABILITY; GUINEA-PIG; NEURONS; RAT; INTERNEURONS; EXPRESSION;
Keywords:
AMPA preferring glutamate receptors; auditory system; cochlear nucleus; cartwheel cells; octopus cells; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, IR Yale Univ, Sch Med, Otolaryngol Sect, POB 208041, New Haven, CT 06520 USA Yale Univ POB 208041 New Haven CT USA 06520 ven, CT 06520 USA
Citazione:
I.R. Schwartz et al., "Differential postsynaptic distribution of GluRs 1-4 on cartwheel and octopus cell somata in the gerbil cochlear nucleus", HEARING RES, 147(1-2), 2000, pp. 70-76

Abstract

Differences were demonstrated in the distribution of glutamate receptors (GluR) 1, 2, 2/3 and 4 postsynaptic immunoreactivity (PSIR) on the somata ofcartwheel and octopus cells in the adult gerbil cochlear nucleus (CN). Montages of electron micrographs of cartwheel and octopus cells immunoreacted with antibodies to GluR 1, 2, 2/3 and 4 were prepared. The number of synaptic terminals with PSIR were counted on all cells for each antibody, normalized to the total length of somatic surface analyzed. The density of terminals apposed to PSIR on octopus cells was similar for the antibodies GluR1, 2/3 and 4, but significantly less for GluR2. On cartwheel somata the numbersof terminals apposed to immunoreactive postsynaptic specializations with GluR 1, 2, 2/3 or 4 were not significantly different from each other. The density of terminals apposed to GluR2/3 and 4 positive postsynaptic specializations was significantly less on cartwheel cells than on octopus somata. The data suggest that the decreased presence of the GluR2 subunit, which confers calcium impermeability to the assembled receptor and slower gating kinetics to receptors with a high GluR4 content, is the major difference in theAMPA receptors on the somata of these cell types. The presence on cartwheel cells of a majority of AMPA receptors which contain GluR2 may account forthe fact that cartwheel cells respond to shocks to the auditory nerve with100 ms excitatory postsynaptic potentials (EPSPs), while octopus cells, most of whose AMPA receptors lack GluR?, respond with 1 ms EPSPs. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:59:08