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Titolo:
Differential distribution of glutamate receptors in the cochlear nuclei
Autore:
Petralia, RS; Rubio, ME; Wang, YX; Wenthold, RJ;
Indirizzi:
NIDCD, NIH, Bethesda, MD 20892 USA NIDCD Bethesda MD USA 20892NIDCD, NIH, Bethesda, MD 20892 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 147, anno: 2000,
pagine: 59 - 69
SICI:
0378-5955(200009)147:1-2<59:DDOGRI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SUBUNIT MESSENGER-RNAS; IN-SITU HYBRIDIZATION; UNIPOLAR BRUSH CELLS; D-ASPARTATE RECEPTOR; AUDITORY BRAIN-STEM; AMPA RECEPTORS; MONOCLONAL-ANTIBODY; GLIAL LOCALIZATIONS; CA2+ PERMEABILITY;
Keywords:
AMPA; NMDA; kainate; metabotropic; endbulb; fusiform cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Petralia, RS NIDCD, NIH, 36-5D08,36 Convent Dr MSC 4162, Bethesda, MD 20892 USA NIDCD 36-5D08,36 Convent Dr MSC 4162 Bethesda MD USA 20892 SA
Citazione:
R.S. Petralia et al., "Differential distribution of glutamate receptors in the cochlear nuclei", HEARING RES, 147(1-2), 2000, pp. 59-69

Abstract

Glutamate receptors are the major excitatory neurotransmitter receptors ofthe mammalian central nervous system, and include AMPA. kainate, delta, NMDA, and metabotropic types. In the cochlear nucleus (CN), the AMPA receptorsubunits GluR2-4 are found in major kinds of neurons, while GluR1 subunit distribution is more restricted. GluR2 is low in the anteroventral CN, suggesting that many AMPA receptors here are calcium-permeable. Delta receptorsare most prevalent in cartwheel cells in the dorsal CN. Of the NMDA receptors, NR1 is widespread while the NR2 subunits show more restricted distributions. Of the metabotropic glutamate receptors, mGluR1 alpha is most prevalent in the dorsal CN, and mGluR2 is concentrated in Golgi cells and unipolar brush cells. AMPA receptors in endbulb synapses in the anteroventral CN are mainly GluR3+4 complexes: probably an adaptation for rapid auditory neurotransmission. Glutamate receptors are differentially distributed in synapses of fusiform cells of the dorsal CN; GluR4 and mGluR1 alpha are present only at basal dendrite synapses (auditory nerve), while other glutamate receptors occupy both apical and basal synapses. Analysis of cytoplasmic distribution suggests that a selective targeting mechanism may restrict movement of GluR4 and mGluR1 alpha to basal dendrites, although other targeting mechanisms may be present. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:44:18