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Titolo:
Nitric oxide in mucosal defense: A little goes a long way
Autore:
Wallace, JL; Miller, MJS;
Indirizzi:
Univ Calgary, Dept Pharmacol & Therapeut, Mucosal Inflammat Res Grp, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 s Grp, Calgary, AB T2N 4N1, Canada Albany Med Coll, Dept Pediat, Albany, NY 12208 USA Albany Med Coll AlbanyNY USA 12208 ll, Dept Pediat, Albany, NY 12208 USA Albany Med Coll, Cardiovasc Res Ctr, Albany, NY 12208 USA Albany Med CollAlbany NY USA 12208 diovasc Res Ctr, Albany, NY 12208 USA
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 2, volume: 119, anno: 2000,
pagine: 512 - 520
SICI:
0016-5085(200008)119:2<512:NOIMDA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXYNITRITE-INDUCED APOPTOSIS; PLATELET-ACTIVATING-FACTOR; NECROSIS-FACTOR-ALPHA; MAST-CELLS; LEUKOCYTE ADHESION; RELAXING FACTOR; RAT STOMACH; GASTRIC MICROCIRCULATION; BACTERIAL TRANSLOCATION; ENDOTOXIN CHALLENGE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Wallace, JL Univ Calgary, Dept Pharmacol & Therapeut, Mucosal Inflammat Res Grp, 3330 Hosp Dr, Calgary, AB T2N 4N1, Canada Univ Calgary 3330 Hosp Dr Calgary AB Canada T2N 4N1 N1, Canada
Citazione:
J.L. Wallace e M.J.S. Miller, "Nitric oxide in mucosal defense: A little goes a long way", GASTROENTY, 119(2), 2000, pp. 512-520

Abstract

Nitric oxide (NO) is now recognized as an important modulator of an enormous number of physiological processes, ranging from blood pressure regulation to neuronal transmission to penile erectile function. In the gastrointestinal tract, NO also participates in many physiological and pathophysiological processes. In this review, we summarize the contribution made by NO to the ability of the gastrointestinal mucosa to resist injury induced by luminal toxins and to defend against microbial invasion. We also review some of the main features of NO chemistry and the potential of NO as a target for new drugs to treat gastrointestinal disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:31:02