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Titolo:
Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma
Autore:
Chen, YJ; Yeh, SH; Chen, JT; Wu, CC; Hsu, MT; Tsai, SF; Chen, PJ; Lin, CH;
Indirizzi:
Natl Yang Ming Univ, Inst Microbiol & Immunol, Sect 2, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 mmunol, Sect 2, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Biochem, Taipei 112, Taiwan Natl Yang Ming UnivTaipei Taiwan 112 , Inst Biochem, Taipei 112, Taiwan Natl Yang Ming Univ, Genet Inst, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 iv, Genet Inst, Taipei 112, Taiwan Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan Natl TaiwanUniv Taipei Taiwan Med, Grad Inst Clin Med, Taipei, Taiwan Taichung Vet Gen Hosp, Dept Pathol, Taichung, Taiwan Taichung Vet Gen Hosp Taichung Taiwan sp, Dept Pathol, Taichung, Taiwan Taichung Vet Gen Hosp, Dept Surg, Taichung, Taiwan Taichung Vet Gen Hosp Taichung Taiwan Hosp, Dept Surg, Taichung, Taiwan
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 2, volume: 119, anno: 2000,
pagine: 431 - 440
SICI:
0016-5085(200008)119:2<431:CCACRB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; HEPATITIS-B VIRUS; CYCLIN D1 AMPLIFICATION; BREAST-CANCER; GENETIC ABERRATIONS; CIRRHOSIS; RESECTION; INFECTION; PROGNOSIS; FEATURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, CH Natl Yang Ming Univ, Inst Microbiol & Immunol, Sect 2, 155 Lin NonSt, Taipei 112, Taiwan Natl Yang Ming Univ 155 Lin Non St Taipei Taiwan 112 112, Taiwan
Citazione:
Y.J. Chen et al., "Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma", GASTROENTY, 119(2), 2000, pp. 431-440

Abstract

Background & Aims: Hepatocellular carcinoma (HCC) is highly malignant and prone to recur after surgical treatment. Differentiation between a true relapse of HCC and a second primary tumor is of clinical importance. However, no convenient method is currently available. Methods: Comparative genomic hybridization (CGH) was used to analyze 31 pairs of initial and recurrent HCC samples obtained from patients undergoing 2 consecutive surgeries, The resulting chromosomal aberration profiles were used as genomic fingerprints to determine tumor clonalities and their relationships, Results: Eleven recurrent tumors with high clonal relationship (CR) values (>0.95) were found to be relapsed HCCs, and 11 tumors with CR values close to 0 were found to be second primary HCCs, The other 9 paired samples had inconclusive CR values between 0.95 and 0.4. Two were confirmed by hepatitis B virus integrationand X chromosome inactivation analysis to be de novo cancers (CR values, 0.35 and 0.23, respectively). Initial HCCs that subsequently relapsed accumulated more chromosomal aberration events than those that developed de novo HCC (mean, 16.1 +/- 4.5 vs. 5.4 +/- 4.8 events; P < 0.01). Also, they more frequently showed gains on chromosome arms 3q, 6p, 8q, and 17q and losses on 4q and 16p, Conclusions: CGH is useful for chromosomal aberration study and tumor clonality analysis. More and characteristic genomic changes in theinitial HCC suggest that subsequent tumor recurrence is a true relapse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:35:59