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Titolo:
A delta opioid receptor lacking the third cytoplasmic loop is generated byatypical mRNA processing in human malignomas
Autore:
Mayer, P; Tischmeyer, H; Jayasinghe, M; Bonnekoh, B; Gollnick, H; Teschemacher, H; Hollt, V;
Indirizzi:
Otto Von Guericke Univ, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Univ Giessen, Rudolf Buchheim Inst Pharmacol, Giessen, Germany Univ Giessen Giessen Germany Buchheim Inst Pharmacol, Giessen, Germany Univ Magdeburg, Clin Dermatol & Venereol, D-39106 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39106 eol, D-39106 Magdeburg, Germany
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 480, anno: 2000,
pagine: 156 - 160
SICI:
0014-5793(20000901)480:2-3<156:ADORLT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MELANOCYTES INVITRO; BETA-ENDORPHIN; FUNCTIONAL EXPRESSION; HUMAN EPIDERMIS; MESSENGER-RNA; MU-OPIATE; IN-VITRO; CELLS; IDENTIFICATION; KERATINOCYTES;
Keywords:
delta opioid receptor; melanocyte; melanoma; skin; neuroblastoma; mRNA processing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Hollt, V Otto Von Guericke Univ, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
P. Mayer et al., "A delta opioid receptor lacking the third cytoplasmic loop is generated byatypical mRNA processing in human malignomas", FEBS LETTER, 480(2-3), 2000, pp. 156-160

Abstract

delta Opioid receptors mere identified in human melanomas by RT-PCR and radioligand binding. In all tumors an additional PCR amplificate was detectedin which 144 bp within the third tron were deleted. This fragment corresponded to the third cytoplasmic domain of the receptor protein, The short variant resulted from atypical mRNA processing, There were no common splice recognition sequences around the deleted fragment; instead its excision resembled the removal of a transposon. The deletion was not detected in normal human melanocytes nor in human or rat brain. However, it mas present in a human neuroblastoma cell line (SH-SY5Y), Thus, it appears that the occurrenceof the short delta opioid receptor is correlated to malignancy. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:56:27