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Titolo:
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Autore:
Krause, A; Neitz, S; Magert, HJ; Schulz, A; Forssmann, WG; Schulz-Knappe, P; Adermann, K;
Indirizzi:
Niedersachs Inst Peptid Forsch, D-30625 Hannover, Germany Niedersachs InstPeptid Forsch Hannover Germany D-30625 annover, Germany
Titolo Testata:
FEBS LETTERS
fascicolo: 2-3, volume: 480, anno: 2000,
pagine: 147 - 150
SICI:
0014-5793(20000901)480:2-3<147:LANHDH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOST-DEFENSE; GENE STRUCTURE; EXPRESSION; POLYPEPTIDES; IDENTIFICATION; ANTIBIOTICS; INNATE;
Keywords:
antimicrobial peptide; liver; hemofiltrate; cysteine-rich peptide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Adermann, K Niedersachs Inst Peptid Forsch, Feodor Lynen Str 31, D-30625 Hannover, Germany Niedersachs Inst Peptid Forsch Feodor Lynen Str 31 Hannover Germany D-30625
Citazione:
A. Krause et al., "LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity", FEBS LETTER, 480(2-3), 2000, pp. 147-150

Abstract

We report the isolation and characterization of a novel human peptide withantimicrobial activity, termed LEAP-1 (liver-expressed antimicrobial peptide). Using a mass spectrometric assay detecting cysteine-rich peptides, a 25-residue peptide containing four disulfide bonds was identified in human blood ultrafiltrate, LEAP-1 expression was predominantly detected in the liver, and, to a much lower extent, in the heart. In radial diffusion assays, Gram-positive Bacillus megaterium, Bacillus subtilis, Micrococcus luteus, Staphylococcus carnosus, and Gram-negative Neisseria cinerea as well as the yeast Saccharomyces cerevisiae dose-dependently exhibited sensitivity upon treatment with synthetic LEAP-1, The discovery of LEAP-1 extends the known families of mammalian peptides with antimicrobial activity by its novel disulfide motif and distinct expression pattern. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:46:00