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Titolo:
Mitochondrial metabolism impairment in muscle fibres of rats chronically intoxicated with Senna occidentalis seeds
Autore:
Calore, EE; Weg, R; Haraguchi, M; Calore, NMP; Cavaliere, MJ; Sesso, A;
Indirizzi:
Emilio Ribas Inst, Sect Pathol, BR-01246900 Sao Paulo, Brazil Emilio RibasInst Sao Paulo Brazil BR-01246900 BC46900 Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Dept Pathol, Lab Mol Pathol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil thol, Lab Mol Pathol, Sao Paulo, Brazil Univ Sao Paulo, Vet Med & Zootechny Sch, Dept Pathol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil hny Sch, Dept Pathol, Sao Paulo, Brazil Inst Biol, Div Anim Biol, Pharmacol Sect, Sao Paulo, Brazil Inst Biol SaoPaulo Brazil Anim Biol, Pharmacol Sect, Sao Paulo, Brazil Adolfo Lutz Inst, Dept Pathol, Sao Paulo, Brazil Adolfo Lutz Inst Sao Paulo Brazil Inst, Dept Pathol, Sao Paulo, Brazil
Titolo Testata:
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
fascicolo: 4, volume: 52, anno: 2000,
pagine: 357 - 363
SICI:
0940-2993(200008)52:4<357:MMIIMF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CASSIA-OCCIDENTALIS; MYOPATHY; NEUROPATHY;
Keywords:
mitochondrial myopathy; muscle diseases; Senna occidentalis; toxic plants; toxic myopathies; mitochondria; myopathy, mitochondrial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Calore, EE Emilio Ribas Inst, Sect Pathol, Av Dr Arnaldo 165, BR-01246900 Sao Paulo, Brazil Emilio Ribas Inst Av Dr Arnaldo 165 Sao Paulo Brazil BR-01246900 BC
Citazione:
E.E. Calore et al., "Mitochondrial metabolism impairment in muscle fibres of rats chronically intoxicated with Senna occidentalis seeds", EXP TOX PAT, 52(4), 2000, pp. 357-363

Abstract

The chronic administration of S. occidentalis seeds was found to induce a mitochondrial myopathy in hens. This study was undertaken to determine if the chronic treatment with S. occidentalis seeds of rats (as a mammalian model) would induce a mitochondrial myopathy similar to those described in humans and to determine if the histological changes could be correlated with the amount of ingested seeds. Twenty-one days old rats were fed S. occidentalis seeds at different diet concentrations (1, 2, 3%). Rats fed 1% S. occidentalis seeds had only a few COX-negative muscle fibbers in the pectoralis major muscle. Rats fed 3% Senna occidentalis seeds had a greater number of COX-negative fibbers. Rats fed 2% had an intermediate number of COX-negative fibbers. Activity of SDH and NADH-rr were decreased in rate, of groups 2%and 3%. Our data indicate that a progressive mitochondrial metabolism impairment can be produced in rats fed S. occidentalis seeds and that this impairment can be correlated with the amount of ingested seeds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:30:34