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Titolo:
Characterization of beta-adrenoceptor subtypes in the ferret urinary bladder in vitro and in vivo
Autore:
Takeda, H; Igawa, Y; Komatsu, Y; Yamazaki, Y; Akahane, M; Nishizawa, O; Ajisawa, Y;
Indirizzi:
Kissei Pharmaceut Co Ltd, Cent Res Lab, Hotaka, Nagano 3998304, Japan Kissei Pharmaceut Co Ltd Hotaka Nagano Japan 3998304 agano 3998304, Japan Shinshu Univ, Sch Med, Dept Urol, Matsumoto, Nagano 3908621, Japan ShinshuUniv Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 403, anno: 2000,
pagine: 147 - 155
SICI:
0014-2999(20000901)403:1-2<147:COBSIT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PUTATIVE BETA(4)-ADRENOCEPTOR; SMOOTH-MUSCLE; FUNCTIONAL EVIDENCE; HUMAN DETRUSOR; MESSENGER-RNA; IN-VITRO; BETA(3)-ADRENOCEPTOR; RAT; AGONISTS; BETA-3-ADRENOCEPTOR;
Keywords:
beta-adrenoceptor, subtype; (ferret); detrusor; cardiovascular system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, H Kissei Pharmaceut Co Ltd, Cent Res Lab, 4365-1, Hotaka, Nagano 3998304, Japan Kissei Pharmaceut Co Ltd 4365-1 Hotaka Nagano Japan 3998304 apan
Citazione:
H. Takeda et al., "Characterization of beta-adrenoceptor subtypes in the ferret urinary bladder in vitro and in vivo", EUR J PHARM, 403(1-2), 2000, pp. 147-155

Abstract

In the present study, the beta-adrenoceptor subtypes distributed in the detrusor of the ferret were investigated in functional experiments in vitro and in vivo using a variety of beta-adrenoceptor agonists and antagonists. All the beta-adrenoceptor agonists tested relaxed the isolated detrusor strip, the rank order of potency being (+/-)-(R*,R*)-[4-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]phenoxy]-acetic acid sodium (BRL 37344A) > (+/-)-4-(3-t-butylamino-2-hydroxypropoxy) benzimidazol-2-one (CGP-12177A), isoprenaline and (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethylamino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243) > dobutamine and procaterol. In antagonist experiment, 3-(2-allylphenoxy)-1-[(1S)-1,2,3,4-tetrahydro-naphth-1-ylamino]-(2S)-2-propanol hydrochloride (SR 58894A), but neither 2-hydroxy-5(2-((2-hydroxy-3-(4-((1-methyl-4-trifluoromethyl)1H-imidazole-2-yl)-phenoxy)propyl)amino)ethoxy)-benzamide monomethane sulphonate (CGP-20712A)nor erythro-(+/-)-1-(7-methylindan-4-yloxy)-3-isopropylaminobutan-2-ol hydrochloride (ICI-118,551), caused a rightward shift of the concentration-relaxation curve for isoprenaline. In in vivo experiments, isoprenaline and CL316,243 each reduced bladder pressure in a dose-dependent manner. CL 316,243 was the only drug that did not produce any significant influences on blood pressure and heart rate at doses that reduced bladder pressure. The present functional study provides the first evidence that relaxation of the ferret detrusor by beta-adrenoceptor activation is mediated mainly via the beta(3)-adrenoceptor, as in the human detrusor. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:06:28