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Titolo:
The beneficial effect of ATP-MgCl2 on hepatic ischemia/reperfusion-inducedmitochondrial dysfunction
Autore:
Jeong, C; Lee, SM;
Indirizzi:
Sung Kyun Kwan Univ, Coll Pharm, Suwon 440746, Kyonggi Do, South Korea Sung Kyun Kwan Univ Suwon Kyonggi Do South Korea 440746 i Do, South Korea
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 403, anno: 2000,
pagine: 243 - 250
SICI:
0014-2999(20000908)403:3<243:TBEOAO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC LIVER-INJURY; RAT-LIVER; ADENOSINE; METABOLISM; REFLOW; REPERFUSION;
Keywords:
ATP-MgCl2; mitochondrial energy metabolism; mitochondrial enzyme; lipid peroxidation; hepatic ischemia/reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, SM Sung Kyun Kwan Univ, Coll Pharm, 300 Chunchun Dong, Suwon 440746, Kyonggi Do, South Korea Sung Kyun Kwan Univ 300 Chunchun Dong Suwon KyonggiDo South Korea 440746
Citazione:
C. Jeong e S.M. Lee, "The beneficial effect of ATP-MgCl2 on hepatic ischemia/reperfusion-inducedmitochondrial dysfunction", EUR J PHARM, 403(3), 2000, pp. 243-250

Abstract

The present study was undertaken to determine whether ATP-MgCl2 administration in rats could protect hepatic mitochondrial function and improve energy metabolism during hepatic ischemia and subsequent reperfusion. Global hepatic ischemia was produced for 60 min followed by reperfusion. The rats then received 0.5 ml of saline or ATP-MgCl2 intravenously. In saline-treated ischemic rats, serum alanine-aminotransferase levels peaked at 5 h. The aminotransferase level was significantly reduced in the ATP-MgCl2 treatment group. The wet weight-to-dry weight ratio of the liver was significantly increased by ischemia/reperfusion. ATP-MgCl2 treatment minimized the increase inthis ratio. The ketone body ratio in blood, which reflects the mitochondrial free NAD(+)/NADH ratio, decreased after ischemia and at 1 h following reperfusion. This decrease was somewhat improved by ATP-MgCl2 infusion. At 1 and 5 h after reperfusion, mitochondrial monoamine oxidase and glutamate dehydrogenase activities decreased. ATP-MgCl2 infusion following ischemia restored the lost activities. Hepatic ATP levels in saline-treated rats were found to be 50% lower 5 h following reperfusion; however, treatment with ATP-MgCl2 resulted in significantly higher ATP levels and energy charge. The accumulation of purine catabolites in ischemic tissues was reduced during reperfusion. ATP-MgCl2 infusion resulted in accumulation of adenosine in reperfused liver. Mitochondrial lipid peroxidation was elevated in the saline-treated ischemic group, but this elevation was inhibited by ATP-MgCl2 infusion. The present results lead us to conclude that the amelioration of liver function which occurs with ATP-MgCl2 infusion following ischemia may be mediated through improvement in ischemia-induced mitochondrial energy metabolism. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:38:22