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Titolo:
Significant regional heterogeneity of coronary flow reserve in paediatric hypertrophic cardiomyopathy
Autore:
Tadamura, E; Yoshibayashi, M; Yonemura, T; Kudoh, T; Kubo, S; Motooka, M; Nohara, R; Matsumori, A; Sasayama, S; Matsuda, T; Tamaki, N; Konishi, J;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 t Imaging, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Pediat, Kyoto, Japan Kyoto Univ Kyoto Japan to Univ, Grad Sch Med, Dept Pediat, Kyoto, Japan Kyoto Univ, Grad Sch Med, Dept Internal Med, Div 3, Kyoto, Japan Kyoto Univ Kyoto Japan Sch Med, Dept Internal Med, Div 3, Kyoto, Japan Kyoto Univ, Grad Sch Med, Dept Med Informat, Kyoto, Japan Kyoto Univ Kyoto Japan v, Grad Sch Med, Dept Med Informat, Kyoto, Japan Hokkaido Univ, Sch Med, Dept Nucl Med, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ed, Sapporo, Hokkaido 060, Japan
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 9, volume: 27, anno: 2000,
pagine: 1340 - 1348
SICI:
0340-6997(200009)27:9<1340:SRHOCF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; LEFT-VENTRICULAR FUNCTION; VASODILATOR RESERVE; PERFUSION ABNORMALITIES; PATHO-PHYSIOLOGY; SUDDEN-DEATH; ISCHEMIA; TL-201; PET;
Keywords:
myocardial blood flow; cardiomyopathy; coronary flow reserve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tadamura, E Kyoto Univ, Grad Sch Med, Dept Nucl Med & Diagnost Imaging, Sakyo Ku, 54 Shogoinkawahara, Kyoto 6068507, Japan Kyoto Univ 54 Shogoinkawahara Kyoto Japan 6068507 8507, Japan
Citazione:
E. Tadamura et al., "Significant regional heterogeneity of coronary flow reserve in paediatric hypertrophic cardiomyopathy", EUR J NUCL, 27(9), 2000, pp. 1340-1348

Abstract

Previous studies have indicated that cardiac events in young patients withhypertrophic cardiomyopathy (HCM) are related to ischaemia rather than to arrhythmia. We measured coronary flow reserve in paediatric HCM and compared the values with those in adult HCM. We studied 12 patients with HCM including six paediatric (<20 years old; mean 13 years) and six adult patients (>20 years old: mean 62 years), and six healthy young adults (mean 29 years)as controls. Every patient underwent magnetic resonance imaging (MRI) for anatomical assessment. Myocardial blood flow at rest and after dipyridamoleinfusion was measured with dynamic nitrogen-13 ammonia positron emission tomography (PET). Partial volume effect was corrected for using the anatomical data obtained with MRI. In adult patients with HCM, coronary flow reserve in the hypertrophied septal region was not significantly different from that in the non-hypertrophied lateral wall (1.38 +/- 0.29 vs 1.77 +/- 0.39, respectively). In the paediatric patients, coronary Row reserve in the hypertrophied septal region was significantly lower than in the non-hypertrophied lateral wall (0.84 +/- 0.33 vs 2.74 +/- 0.90, respectively, P < 0.01). In addition, coronary flow reserve in adult patients was lower than in control subjects both in the septal wall (1.38 +/- 0.29 vs 2.94 +/- 0.35, respectively, P < 0.0001) and in the lateral wall (1.771 +/- 0.39 vs 2.85 +/- 0.69, respectively, P < 0.05). In contrast, coronary flow reserve in paediatric patients was not significantly different from that in control subjects inthe lateral wall (2.74 +/- 0.90 vs 2.85 +/- 0.69, respectively), while absolute reduction of myocardial blood flow was noted after pharmacological vasodilatation in the hypertrophied septal region. In conclusion, significantregional differences of coronary flow reserve were present in the paediatric patients with HCM. These results suggest that paediatric patients with HCM intrinsically have the potential to experience significant regional ischaemia even in the absence of coronary stenosis.

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Documento generato il 31/03/20 alle ore 10:20:46