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Titolo:
FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy
Autore:
Franzius, C; Sciuk, J; Daldrup-Link, HE; Jurgens, H; Schober, O;
Indirizzi:
Univ Hosp, Dept Nucl Med, Munster, Germany Univ Hosp Munster GermanyUniv Hosp, Dept Nucl Med, Munster, Germany Univ Hosp, Dept Clin Radiol, Munster, Germany Univ Hosp Munster GermanyUniv Hosp, Dept Clin Radiol, Munster, Germany Univ Hosp, Dept Pediat Hematol & Oncol, Munster, Germany Univ Hosp Munster Germany Dept Pediat Hematol & Oncol, Munster, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 9, volume: 27, anno: 2000,
pagine: 1305 - 1311
SICI:
0340-6997(200009)27:9<1305:FFDOOM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; CANCER; OSTEOSARCOMA; CHEMOTHERAPY; THERAPY; SARCOMA; TUMORS;
Keywords:
fluorine-18 fluorodeoxyglucose; positron emission tomography; bone scintigraphy; malignant primary bone tumours; osseous metastases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Franzius, C Univ Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48149Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
C. Franzius et al., "FDG-PET for detection of osseous metastases from malignant primary bone tumours: comparison with bone scintigraphy", EUR J NUCL, 27(9), 2000, pp. 1305-1311

Abstract

The purpose of this study was to compare positron emission tomography using fluorine-18 fluorodeoxyglucose (FDG-PET) and technetium-99m methylene diphosphonate (MDP) bone scintigraphy in the detection of osseous metastases from malignant primary osseous rumours. In 70 patients with histologically proven malignant primary bone rumours (32 osteosarcomas, 38 Ewing's sarcomas), 118 FDG-PET examinations were evaluated. FDG-PET scans were analysed with regard to osseous metastases in comparison with bone scintigraphy. The reference methods for both imaging modalities were histopathological analysis, morphological imaging [additional conventional radiography, computed tomography (CT) or magnetic resonance imaging (MRI)] and/or clinical follow-up over 6-64 months (median 20 months). In 21 examinations (18%) reference methods revealed 54 osseous metastases (49 from Ewing's sarcomas, five from osteosarcomas). FDG-PET had a sensitivity of 0.90, a specificity of 0.96 and an accuracy of 0.95 on an examination-based analysis. Comparable values forbone scintigraphy were 0.71, 0.92 and 0.88. On a lesion-based analysis thesensitivity of FDG-PET and bone scintigraphy was 0.80 and 0.72, respectively. Analysing only Ewing's sarcoma patients, the sensitivity, specificity and accuracy of FDG-PET and bone scan were 1.00, 0.96 and 0.97 and 0.68, 0.87 and 0.82, respectively (examination-based analysis). None of the five osseous metastases from osteosarcoma were detected by FDG-PET, but all of themwere true-positive using bone scintigraphy. In conclusion, the sensitivity, specificity and accuracy of FDG-PET in the detection of osseous metastases from Ewing's sarcomas are superior to those of bone scintigraphy. However, in the detection of osseous metastases from osteosarcoma, FDG-PET seems to be less sensitive than bone scintigraphy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 00:48:54