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Titolo:
And analysis of the gene encoding the human neonatal Fc receptor
Autore:
Mikulska, JE; Pablo, L; Canel, J; Simister, NE;
Indirizzi:
Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland Polish Acad Sci Wroclaw Poland PL-53114 herapy, PL-53114 Wroclaw, Poland Brandeis Univ, Rosenstiel Ctr Basic Biomed Sci, Waltham, MA 02254 USA Brandeis Univ Waltham MA USA 02254 asic Biomed Sci, Waltham, MA 02254 USA Brandeis Univ, WM Keck Inst Cellular Visualizat, Waltham, MA 02254 USA Brandeis Univ Waltham MA USA 02254 ular Visualizat, Waltham, MA 02254 USA Brandeis Univ, Dept Biol, Waltham, MA 02254 USA Brandeis Univ Waltham MA USA 02254 Univ, Dept Biol, Waltham, MA 02254 USA
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOGENETICS
fascicolo: 4, volume: 27, anno: 2000,
pagine: 231 - 240
SICI:
0960-7420(200008)27:4<231:AAOTGE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; I-RELATED RECEPTOR; NUCLEOTIDE-SEQUENCE; HUMAN PLACENTA; HUMAN ZN-ALPHA(2)-GLYCOPROTEIN; CHROMOSOMAL ASSIGNMENT; ANTIBODY TRANSPORT; IGG TRANSPORTER; REPETITIVE DNA; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Simister, NE Brandeis Univ, MS 029,415 South St, Waltham, MA 02454 USA Brandeis Univ MS 029,415 South St Waltham MA USA 02454 54 USA
Citazione:
J.E. Mikulska et al., "And analysis of the gene encoding the human neonatal Fc receptor", EUR J IMM, 27(4), 2000, pp. 231-240

Abstract

The neonatal Fc receptor, FcRn, is expressed in human placental syncytiotrophoblast, capillary endothelium, intestinal epithelium, and other tissues. By analogy with its role in the mouse, human FcRn is expected to transportmaternal IgG to the foetus, and protect circulating IgG from catabolism. The larger subunit of FcRn is homologous to the a chains of the major histocompatibility complex (MHC) class I proteins, but is encoded outside the MHCon chromosome 19. We report the isolation of clones encoding the a chain of human FcRn from chromosome 19-specific libraries. The sequence revealed asimilar organization to classical and non-classical MHC, and MHC-related genes. Compared with classical MHC class I genes, the human FcRn a chain gene has expanded by acquiring many repetitive sequences in its introns, including multiple Alu elements in the fourth intron. Primer extension analysis showed that there are two transcription initiation sites in the upstream flanking sequence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:58:51