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Titolo:
The cell biology of ion pumps: sorting and regulation
Autore:
Dunbar, LA; Caplan, MJ;
Indirizzi:
Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06525 USA Yale Univ New Haven CT USA 06525 r & Mol Physiol, New Haven, CT 06525 USA
Titolo Testata:
EUROPEAN JOURNAL OF CELL BIOLOGY
fascicolo: 8, volume: 79, anno: 2000,
pagine: 557 - 563
SICI:
0171-9335(200008)79:8<557:TCBOIP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLARIZED EPITHELIAL-CELLS; PROTEIN-KINASE-C; NA,K-ATPASE ALPHA-SUBUNIT; GASTRIC-ACID SECRETION; GPI-ANCHORED PROTEINS; RAT RENAL NA+; K+-ATPASE; BETA-SUBUNIT; PARIETAL-CELL; TUBULE CELLS;
Keywords:
ion pump; polarity; sorting; epithelia; regulation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Caplan, MJ Yale Univ, Sch Med, Dept Cellular & Mol Physiol, 333 Cedar St, New Haven, CT 06525 USA Yale Univ 333 Cedar St New Haven CT USA 06525 ven, CT 06525 USA
Citazione:
L.A. Dunbar e M.J. Caplan, "The cell biology of ion pumps: sorting and regulation", EUR J CELL, 79(8), 2000, pp. 557-563

Abstract

The physiologic function of an ion pump is determined, in part, by its subcellular localization and by the cellular mechanisms that modulate its activity The Na,K-ATPase and the gastric H,K-ATPase are two closely related members of the P-type family of ion transporting ATPases, Despite their homology; these pumps are sorted to different domains in polarized epithelial cells and their enzymatic activities are subject to distinct regulatory pathways. The molecular signals responsible for these properties have begun to beelucidated, It appears that a complex array of inter- and intra-molecular interactions govern these proteins' trafficking, distribution and catalyticcapacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:58:49