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Titolo:
Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation
Autore:
Dachs, GU; Tozer, GM;
Indirizzi:
Mt Vernon Hosp, Gray Lab Canc Res Trust, Tumor Microcirculat Grp, Northwood HA6 2JR, Middx, England Mt Vernon Hosp Northwood Middx England HA6 2JR od HA6 2JR, Middx, England
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 13, volume: 36, anno: 2000,
pagine: 1649 - 1660
SICI:
0959-8049(200008)36:13<1649:HMGEAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE-SYNTHASE; FACTOR MESSENGER-RNA; INDUCIBLE FACTOR-I; FACTOR THYMIDINE PHOSPHORYLASE; UBIQUITIN-PROTEASOME PATHWAY; INTERNAL RIBOSOME ENTRY; ARGININE METHYL-ESTER; MURINE TUMOR-CELLS; TRANSCRIPTION FACTOR;
Keywords:
hypoxia inducible factor-1; vascular endothelial growth factor; nitric oxide synthase; gene therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
156
Recensione:
Indirizzi per estratti:
Indirizzo: Dachs, GU Mt Vernon Hosp, Gray Lab Canc Res Trust, Tumor Microcirculat Grp, POB 100,Northwood HA6 2JR, Middx, England Mt Vernon Hosp POB 100 Northwood Middx England HA6 2JR , England
Citazione:
G.U. Dachs e G.M. Tozer, "Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation", EUR J CANC, 36(13), 2000, pp. 1649-1660

Abstract

Tumour hypoxia is the result of an imbalance in oxygen supply and demand. It is an adverse prognostic indicator in cancer as it modulates tumour progression and treatment. Many genes controlling tumour biology are oxygen regulated, and new ones are constantly added to the growing list of hypoxia-induced genes. Of specific importance are hypoxia-responsive transcription factors, as they can modulate the expression of numerous different genes. Similarly, growth factors which govern the formation of new blood vessels or which control blood flow are vitally important for both the maintenance of the primary tumour and metastases at distant sites. The purpose of this review is to present an update of selected issues regarding hypoxia-inducible gene expression and how this affects prognosis, angiogenesis and metastasis. It will conclude by discussing gene therapy as one possible means of exploiting tumour hypoxia for the treatment of cancer. (C) 2000 Elsevier ScienceLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 22:14:32