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Titolo:
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation
Autore:
Beavon, IRG;
Indirizzi:
S African Inst Med Res, Sch Pathol, Dept Anat Pathol, Johannesburg, South Africa S African Inst Med Res Johannesburg South Africa nnesburg, South Africa Univ Witwatersrand, Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa Johannesburg, South Africa
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 13, volume: 36, anno: 2000,
pagine: 1607 - 1620
SICI:
0959-8049(200008)36:13<1607:TECITM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL ADHESION; EPIDERMAL GROWTH-FACTOR; HUMAN GASTRIC CARCINOMAS; MOLECULE E-CADHERIN; FACTOR-RECEPTOR EXPRESSION; TYROSINE KINASE SUBSTRATE; AUTOCRINE MOTILITY FACTOR; HUMAN ESOPHAGEAL CANCER; HUMAN ENDOTHELIAL-CELLS; LYMPH-NODE METASTASIS;
Keywords:
E-cadherin; catenins; cell adhesion; cell signalling; regulation; tumour metastasis; hypoxia; growth factors; epidermal growth factor receptor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
204
Recensione:
Indirizzi per estratti:
Indirizzo: Beavon, IRG S African Inst Med Res, Sch Pathol, Dept Anat Pathol, Johannesburg, South Africa S African Inst Med Res Johannesburg South Africa uth Africa
Citazione:
I.R.G. Beavon, "The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation", EUR J CANC, 36(13), 2000, pp. 1607-1620

Abstract

E-cadherin and the associated catenin complex have been recognised as performing a key role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to tumour metastasis. The ability of both extra- and intracellular factors to regulate E-cadherin-mediated cell adhesion in physiological processes has provided insight into both the interactions of the E-cadherin-catenin complex, and possible mechanisms utilised by tumours in the process of metastasis. The interaction of thr E-cadherin-catenin complex with various regulating factors, their effect on cell signalling pathways, and the relationship with the metastatic potential of tumours are reviewed. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:33:58