Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats
Autore:
Borowicz, KK; Kleinrok, Z; Czuczwar, SJ;
Indirizzi:
Med Univ, Dept Pathophysiol, PL-20090 Lublin, Poland Med Univ Lublin Poland PL-20090 pt Pathophysiol, PL-20090 Lublin, Poland Med Univ, Dept Pharmacol & Toxicol, PL-20090 Lublin, Poland Med Univ Lublin Poland PL-20090 macol & Toxicol, PL-20090 Lublin, Poland Inst Agr Med, Isotope Lab, Lublin, Poland Inst Agr Med Lublin PolandInst Agr Med, Isotope Lab, Lublin, Poland
Titolo Testata:
EPILEPSIA
fascicolo: 9, volume: 41, anno: 2000,
pagine: 1112 - 1118
SICI:
0013-9580(200009)41:9<1112:7DATAA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; PILOCARPINE-INDUCED SEIZURES; L-ARGININE; MONOAMINE-OXIDASE; RNA EXPRESSION; ANIMAL-MODELS; MICE; INHIBITOR; EPILEPSY; MESSENGER;
Keywords:
7-nitroindazole; nitric oxide; antiepileptic drugs; seizures;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Czuczwar, SJ Med Univ, Dept Pathophysiol, Jaczewskiego 8, PL-20090 Lublin,Poland Med Univ Jaczewskiego 8 Lublin Poland PL-20090 ublin, Poland
Citazione:
K.K. Borowicz et al., "7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats", EPILEPSIA, 41(9), 2000, pp. 1112-1118

Abstract

Purpose: The objective of this study was to evaluate the interaction of the preferential brain nitric oxide synthase (NOS) inhibitor, 7-nitroindazole(7-NI), with conventional antiepileptic drugs (AEDs) against amygdala-kindled seizures in rats. Methods: Experiments were performed on fully kindled rats. Adverse effectswere evaluated with the rotorod test, which assesses motor coordination, and the passive-avoidance task, which assesses memory. Plasma levels of AEDswere measured by immunofluorescence. Results: 7-NI (up to 100 mg/kg) failed to modify seizure parameters. However, it reduced the severity and duration of kindled seizures when coadministered with otherwise ineffective doses of carbamazepine (CBZ) (10-20 mg/kg)or phenobarbital (PB) (20 mg/kg). Combinations of 7-NI with valproate (VPA), diphenylhydantoin (DPH), or clonazepam (CLO) were not protective. L-Arginine (500 mg/kg) did not reverse the seizure-suppressing interactions between 7-NI and the conventional AEDs. The combinations of 7-NI and CBZ or PB did not impair performance in the rotorod test. Coadministration of 7-NI with CBZ did not affect long-term memory, and 7-NI given with PB didn't affectthe mnemonic effect of PB. Finally, 7-NI did not affect the free plasma levels of CBZ or PB. Conclusions: Pharmacokinetic interactions de, not seem to account for the anticonvulsant effects of 7-NI combined with CBZ or PB. Central nitric oxide (NO) is possibly not involved in the synergism between 7-NI and these AEDs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 14:12:59