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Titolo:
Distribution of autoantibodies to glutamic acid decarboxylase across the spectrum of diabetes mellitus seen in South Africa
Autore:
Panz, VR; Kalk, WJ; Zouvanis, M; Joffe, BI;
Indirizzi:
Univ Witwatersrand, Sch Med, Dept Med, Carbohydrate & Lipid Metab Res Grp,ZA-2193 Johannesburg, South Africa Univ Witwatersrand Johannesburg South Africa ZA-2193 sburg, South Africa
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 7, volume: 17, anno: 2000,
pagine: 524 - 527
SICI:
0742-3071(200007)17:7<524:DOATGA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-CELL ANTIBODIES; INSULIN; ASSAY; PATHOGENESIS; ANTIGENS; GAD(65); DISEASE; IDDM;
Keywords:
African subjects; diabetes mellitus subtypes; GAD autoantibodies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Panz, VR Univ Witwatersrand, Sch Med, Dept Med, Carbohydrate & Lipid MetabRes Grp,7 York Rd, ZA-2193 Johannesburg, South Africa Univ Witwatersrand 7York Rd Johannesburg South Africa ZA-2193 a
Citazione:
V.R. Panz et al., "Distribution of autoantibodies to glutamic acid decarboxylase across the spectrum of diabetes mellitus seen in South Africa", DIABET MED, 17(7), 2000, pp. 524-527

Abstract

Aims This study investigated the association between glutamic acid decarboxylase antibodies (GAD-AB) and Type 1, Type 2, pancreatic and lipoatrophic diabetes mellitus (DM) in South African patients. Methods Four groups were selected: group A, 100 Black Type 1 DM patients (age at onset < 35 years, body mass index (BMI) < 27 kg/m(2) and insulin dependent within 1 year of presentation); group B, 80 Black Type 2 DM patients(age at onset > 35 years, BMI > 27 kg/m(2) and controlled on oral hypoglycaemic agents for at least 1 year after presentation); group C, 10 patients of varying ethnicity with DM or impaired glucose tolerance secondary to chronic pancreatitis; group D, five patients of varying ethnicity with DM associated with total lipodystrophy. Fifty healthy Black control subjects were also studied (group E). Serum GAD-AB and random C-peptide levels were measured by radioimmunoassay. Results Mean C-peptide concentration was significantly lower in Type 1 DM patients than Type 2 DM patients (P < 0.00001). Forty-four patients with Type 1 DM were GAD-AB-positive compared to two patients with Type 2 DM. Two control subjects were also GAD-AB-positive. No patient in the other groups had a titre > 1 U/ml. Type 1 DM patients who were GAD-AB-positive did not differ from those who were GAD-AB-negative for age at onset, duration of DM or C-peptide concentrations. Conclusions Auto-immune beta-cell destruction has an important role in thepathogenesis of Type 1 DM amongst African patients. However, Type 2 African DM patients and other diabetes subtypes are largely GAD-AB-negative.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:52:35