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Titolo:
Sex differences in the response of postnatal rat lumbar lamina X neurons to exogenously applied galanin recorded in vitro
Autore:
Phelan, KD; Newton, BW;
Indirizzi:
Univ Arkansas Med Sci, Dept Anat, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA Univ Arkansas Med Sci, Arkansas Ctr Neurosci, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 122, anno: 2000,
pagine: 157 - 163
SICI:
0165-3806(20000830)122:2<157:SDITRO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; LUMBOSACRAL SPINAL-CORD; NOCICEPTIVE FLEXOR REFLEX; LOCUS-COERULEUS NEURONS; INTRATHECAL GALANIN; NEUROENDOCRINE PEPTIDE; RECEPTOR ANTAGONISTS; VENTRAL HIPPOCAMPUS; ANTERIOR-PITUITARY; ANDROGEN RECEPTORS;
Keywords:
intracellular recording; nociception; pain; slice preparation; sexual dimorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Phelan, KD Univ Arkansas Med Sci, Dept Anat, Slot 510,4301 W Markham St, Little Rock,AR 72205 USA Univ Arkansas Med Sci Slot 510,4301 W Markham St Little Rock AR USA 72205
Citazione:
K.D. Phelan e B.W. Newton, "Sex differences in the response of postnatal rat lumbar lamina X neurons to exogenously applied galanin recorded in vitro", DEV BRAIN R, 122(2), 2000, pp. 157-163

Abstract

Intracellular recording techniques were used in a horizontal slice preparation of postnatal rat lumbar spinal cord to compare the responses of male and female lamina X neurons to exogenously applied galanin. Although there was no significant sex difference in the resting membrane potential or inputresistance of neurons, superfusion of galanin 1-16 (1 mu M) produced a membrane hyperpolarization that averaged -5.3 mV in males and only -2.0 mV in females. The galanin-induced membrane hyperpolarization of lamina X neuronswas accompanied by an inconsistent and varied change in input resistance. No depolarizing effect of galanin was detected in either sex. Galanin did not significantly alter the spike shape, amplitude, after hyperpolarization or locally evoked synaptic responses. The more than 2.5 fold significant sex difference in response to galanin occurred at a developmental timepoint at which lamina X expressed a comparably higher amount of galanin-like immunoreactivity in males compared to females. These results provide the first indication of a sex difference in the response of lamina X neurons to any neuropeptide. Given the antinociceptive role of galanin in the spinal cord, these results raise the possibility for the presence of distinct. physiological and anatomical substrates for sex-dependent differences in nociceptive processing in lamina X of the lumbosacral spinal cord. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:56:25