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Titolo:
Remarkable roles of proteolysis on and beyond the cell surface
Autore:
Blobel, CP;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Cellular Biochem & Biophys Program, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New YorkNY USA 10021 New York, NY 10021 USA
Titolo Testata:
CURRENT OPINION IN CELL BIOLOGY
fascicolo: 5, volume: 12, anno: 2000,
pagine: 606 - 612
SICI:
0955-0674(200010)12:5<606:RROPOA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; AMYLOID PRECURSOR PROTEIN; CAENORHABDITIS-ELEGANS; SECRETASE CLEAVAGE; BETA-SECRETASE; MATRIX METALLOPROTEINASES; INTRACELLULAR DOMAIN; ALZHEIMERS-DISEASE; CONVERTING-ENZYME; NUCLEAR ACCESS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Blobel, CP Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Cellular Biochem & Biophys Program, Box 368,1275 York Ave, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr Box 368,1275 York Ave New York NY USA 10021
Citazione:
C.P. Blobel, "Remarkable roles of proteolysis on and beyond the cell surface", CURR OP CEL, 12(5), 2000, pp. 606-612

Abstract

Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EG F-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:01:12