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Titolo:
Molecular mechanisms of renal sulfate regulation
Autore:
Morris, ME; Sagawa, K;
Indirizzi:
SUNY Buffalo, Sch Pharm, Dept Pharmaceut, Buffalo, NY 14260 USA SUNY Buffalo Buffalo NY USA 14260 Dept Pharmaceut, Buffalo, NY 14260 USA
Titolo Testata:
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
fascicolo: 4, volume: 37, anno: 2000,
pagine: 345 - 388
SICI:
1040-8363(2000)37:4<345:MMORSR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BORDER MEMBRANE-VESICLES; ALTERED DIETARY SULFATE; INORGANIC SULFATE; BRUSH-BORDER; RAT-KIDNEY; PROXIMAL TUBULE; TRANSPORT PROTEIN; GENE ENCODES; 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE; BASOLATERAL MEMBRANE;
Keywords:
inorganic sulfate; hormones; NaSi-1; sat-1; kidney; reabsorption;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
157
Recensione:
Indirizzi per estratti:
Indirizzo: Morris, ME SUNY Buffalo, Sch Pharm, Dept Pharmaceut, Buffalo, NY 14260 USASUNY Buffalo Buffalo NY USA 14260 aceut, Buffalo, NY 14260 USA
Citazione:
M.E. Morris e K. Sagawa, "Molecular mechanisms of renal sulfate regulation", CR R CL LAB, 37(4), 2000, pp. 345-388

Abstract

Inorganic sulfate is an important physiological anion that is a required cofactor for sulfate conjugation reactions of both endogenous and exogenous compounds. It is necessary for the detoxification of xenobiotics and endogenous compounds (catecholamines, steroids, bile acids), for the synthesis ofstructural components of membranes and tissues (sulfated glycosaminoglycans), and for the biologic activity of endogenous compounds (heparin and cholecystokinin). Inorganic sulfate homeostasis is largely maintained by reabsorption in the renal proximal tubule. Sodium-dependent sulfate cotransport in the brush border membrane is of primary importance in the regulation of plasma inorganic sulfate concentrations. Altered renal reabsorption of sulfate has been observed under different physiological (age, pregnancy, low dietary intake), pathological (hypothyroidism, trace metal excess), and pharmacological conditions (treatment with nonsteroidal antiinflammatory agents). The recent identification of the sulfate transporter genes has allowed theinvestigation of the molecular mechanisms of altered sulfate transport. Although the regulation of sulfate homeostasis is not fully understood, recent investigations have explored the cellular mechanisms of some of these alterations. In this review, the physiological importance of inorganic sulfate, the availability of this anion, and the regulation of sulfate homeostasisare discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:36:01