Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The clinical chemistry of inorganic sulfate
Autore:
Cole, DEC; Evrovski, J;
Indirizzi:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada Lab Med & Pathobiol, Toronto, ON, Canada Univ Toronto, Dept Med, Toronto, ON, Canada Univ Toronto Toronto ON Canada iv Toronto, Dept Med, Toronto, ON, Canada Univ Toronto, Dept Paediat, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Dept Paediat, Toronto, ON, Canada Toronto Gen Hosp, Dept Clin Chem, Toronto, ON, Canada Toronto Gen Hosp Toronto ON Canada , Dept Clin Chem, Toronto, ON, Canada
Titolo Testata:
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
fascicolo: 4, volume: 37, anno: 2000,
pagine: 299 - 344
SICI:
1040-8363(2000)37:4<299:TCCOIS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRUSH-BORDER MEMBRANE; CHRONIC-RENAL-FAILURE; SULFITE OXIDASE DEFICIENCY; 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE PAPS; TOTAL PARENTERAL-NUTRITION; FLOW ANION CHROMATOGRAPHY; INCREASED SERUM SULFATE; ACHONDROGENESIS TYPE IB; AMINO-ACID-METABOLISM; CYSTIC-FIBROSIS;
Keywords:
inorganic sulfate; clinical chemistry; serum; urine; biological fluids;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
285
Recensione:
Indirizzi per estratti:
Indirizzo: Cole, DEC Banting Inst, Dept Lab Med & Pathobiol, Rm 402,100 Coll St, Toronto, ON M5G 1L5, Canada Banting Inst Rm 402,100 Coll St Toronto ON Canada M5G 1L5 Canada
Citazione:
D.E.C. Cole e J. Evrovski, "The clinical chemistry of inorganic sulfate", CR R CL LAB, 37(4), 2000, pp. 299-344

Abstract

Although inorganic sulfate is an essential and ubiquitous anion in human biology, it is infrequently assayed in clinical chemistry today. Serum sulfate is difficult to measure accurately without resorting to physicochemical methods, such as ion chromatography, although many other techniques have been described. It is strongly influenced by a variety of physiological factors, including age, diet, pregnancy, and drug ingestion. Urinary excretion is the principal mechanism of disposal for the excess sulfate produced by sulfur amino acid oxidation, and the kidney is the primary site of regulation. In renal failure, sulfoesters accumulate and hypersulfatemia contributes directly to the unmeasured anion gap characteristic of the condition. In contrast, sulfate in urine is readily assayed by a number of means, particularly nephelometry after precipitation as a barium salt. Sulfate is most commonly assayed today as part of the clinical workup for nephrolithiasis, because sulfate is a major contributor to the ionic strength of urine and alters the equilibrium constants governing saturation and precipitation of calcium salts. Total sulfate deficiency has hitherto not been described, although genetic defects in sulfate transporters have been associated recently with congenital osteochondrodystrophies that may be lethal. New insights into sulfate transport and its hormonal regulation may lend to new clinical applications of sulfate analysis in the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 06:44:50