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Titolo:
Genetically targeted calcium sensors enhance the study of organelle function in living cells
Autore:
Petrou, S; Bowser, DN; Nicholls, RA; Panchal, RG; Smart, ML; Reilly, AM; Williams, DA;
Indirizzi:
Univ Melbourne, Dept Physiol, Confocal & Fluorescence Imaging Grp, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia Univ Melbourne, Dept Physiol, Mol Physiol Lab, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 9, volume: 27, anno: 2000,
pagine: 738 - 744
SICI:
0305-1870(200009)27:9<738:GTCSET>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREEN FLUORESCENT PROTEINS; SMOOTH-MUSCLE CELLS; NUCLEAR CALCIUM; CA2+; ELEMENTARY; AEQUORIN; STORE;
Keywords:
calcium; cameleons; camgaroos; cardiac cells; fluorescence imaging; mitochondria; nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, DA Univ Melbourne, Dept Physiol, Confocal & Fluorescence ImagingGrp, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 3010, Australia
Citazione:
S. Petrou et al., "Genetically targeted calcium sensors enhance the study of organelle function in living cells", CLIN EXP PH, 27(9), 2000, pp. 738-744

Abstract

1, Understanding the regulation of calcium (Ca2+), the most common of the mineral ions within the human body; has always been of extreme interest to physiologists. While the importance of Ca2+ in contributing to physiological events through regulation of levels has been significantly established, seldom is consideration given to the intricacies of this ion and its mechanics in producing such diverse physiological responses in different regions of the cell,2, The present review will summarize new methodologies used in our laboratories for the study of two major intracellular organelles, mitochondria andthe nucleus, These techniques are based predominantly on the use of molecular biological approaches to both create and then target protein-based sensor molecules to specific intracellular locations.3, The regulation of Ca2+ in the mitochondria and nucleus is of particularinterest to us because of the central involvement of these organelles in: (i) cardiac cell responses during ischaemia/reperfusion; and (ii) the control of gene expression, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:17:13