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Titolo:
Activity of the Na+/H+ exchanger contributes to cardiac damage following ischaemia and reperfusion
Autore:
Allen, DG; Xiao, XH;
Indirizzi:
Univ Sydney, Dept Physiol F13, Inst Biomed Res, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ed Res, Sydney, NSW 2006, Australia
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 9, volume: 27, anno: 2000,
pagine: 727 - 733
SICI:
0305-1870(200009)27:9<727:AOTNEC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-HYDROGEN-EXCHANGE; PROTEIN-KINASE-C; RAT VENTRICULAR MYOCYTES; H+ EXCHANGE; INTRACELLULAR PH; STUNNED MYOCARDIUM; POSTISCHEMIC RECOVERY; CONTRACTILE FAILURE; ISCHEMIC MYOCARDIUM; POTASSIUM CHANNELS;
Keywords:
ischaemia; Na+/H+ exchanger; NHE1; preconditioning; reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Allen, DG Univ Sydney, Dept Physiol F13, Inst Biomed Res, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 dney, NSW 2006, Australia
Citazione:
D.G. Allen e X.H. Xiao, "Activity of the Na+/H+ exchanger contributes to cardiac damage following ischaemia and reperfusion", CLIN EXP PH, 27(9), 2000, pp. 727-733

Abstract

1. The present review considers the evidence that Na+-H+ exchange activitycontributes to cardiac damage following ischaemia and reperfusion, The basic mechanism involved is that protons are produced during ischaemia and leave the myocytes on the Na+/H+ exchanger during either ischaemia and/or reperfusion, The resulting elevation of [Na+](i) causes Ca2+ loading through the Na+/Ca2+ exchanger and the elevated [Ca2+](i) is thought to lead to myocardial damage,2. Inhibition of the Na+/H+ exchanger during ischaemia and/or reperfusion produces a substantial cardioprotective effect by blocking the damage caused by the coupled exchanger mechanism described above. Preconditioning also produces a cardioprotective effect and the evidence that this also involvesthe Na+/H+ exchanger is reviewed,3, The intracellular mechanisms associated with ischaemic damage and preconditioning are of great interest because they may provide targets for potential therapeutic interventions. The intracellular regulation of the Na+/H+ exchanger appears to be an important component of these pathways and may become a focus for therapeutic approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:55:45