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Titolo:
Acute and chronic sympathoinhibition on carotid artery diameter of spontaneously hypertensive rats: Effects of clonidine and flesinoxan
Autore:
Dabire, H; Chamiot-Clerc, P; Chaouche-Teyara, K; Fournier, B; Safar, ME;
Indirizzi:
INSERM, U337, Paris, France INSERM Paris FranceINSERM, U337, Paris, France
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 9, volume: 27, anno: 2000,
pagine: 715 - 723
SICI:
0305-1870(200009)27:9<715:AACSOC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIHYPERTENSIVE AGENT; IMIDAZOLE RECEPTORS; PRESSURE; RILMENIDINE; RESPONSES; SUBTYPE; SYSTEM; TONE;
Keywords:
carotid artery diameter; centrally acting antihypertensive agents; chronic treatments; conscious animal; spontaneously hypertensive rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Safar, ME Hop Broussais, 96 Rue Didot, F-75674 Paris 14, France Hop Broussais 96 Rue Didot Paris France 14 674 Paris 14, France
Citazione:
H. Dabire et al., "Acute and chronic sympathoinhibition on carotid artery diameter of spontaneously hypertensive rats: Effects of clonidine and flesinoxan", CLIN EXP PH, 27(9), 2000, pp. 715-723

Abstract

1. Hypertensive conduit arteries are thicker and stiffer than those of normotensive controls. Whether they are specifically sensitive to central sympathoinhibition has never been investigated.2. The effects of acute (24 h infusion) and chronic (4 week infusion) treatments with clonidine (0.01 and 0.1 mg/kg per day) and flesinoxan (1 and 3 mg/kg per day) on carotid artery diameter were investigated in spontaneously hypertensive rats. At the end of treatment, blood pressure (BP) was recorded in the rats while they were conscious, Rats were then anaesthetized forcarotid artery diameter measurements using an ultrasonic echo-tracking device.3, In conscious rats, clonidine significantly decreased BP and heart rate (HR) following acute but not chronic treatment. In contrast, flesinoxan significantly decreased BP following both the acute and chronic treatment, In anaesthetized animals, the two agents have opposite effects on isobaric carotid artery diameter, with a decrease under clonidine and an increase underflesinoxan. After 1 weeks infusion, the reactivity of aortic rings was studied in organ chambers. Flesinoxan, but not clonidine, caused the relaxation of potassium chloride precontracted aortic segments.4. The results indicate that although clonidine and flesinoxan are centrally acting antihypertensive agents, the drug-induced changes in isobaric carotid diameter may be influenced by local factors independent of the centralaction of the two drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:37:58