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Titolo:
Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients
Autore:
Cimerman, N; Brguljan, PM; Krasovec, M; Suskovic, S; Kos, J;
Indirizzi:
KRKA DD, Div Res & Dev, Dept Biochem Res & Drug Design, Ljubljana, Slovenia KRKA DD Ljubljana Slovenia ochem Res & Drug Design, Ljubljana, Slovenia Univ Golnik, Clin Resp & Allerg Dis, Golnik 4204, Slovenia Univ Golnik Golnik Slovenia 4204 esp & Allerg Dis, Golnik 4204, Slovenia Jozef Stefan Inst, Dept Biochem & Mol Biol, Ljubljana 1000, Slovenia JozefStefan Inst Ljubljana Slovenia 1000 Biol, Ljubljana 1000, Slovenia
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 300, anno: 2000,
pagine: 83 - 95
SICI:
0009-8981(200010)300:1-2<83:SCCAPI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; CATHEPSIN-B; ALVEOLAR MACROPHAGES; REFERENCE INTERVALS; CYCLOSPORINE-A; GAMMA-TRACE; STEFIN-A; MARKER; CREATININE; IMMUNOASSAY;
Keywords:
asthma; cystatin C; creatinine; serum; 24-h variations; cyclosporin A; methylprednisolone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cimerman, N KRKA DD, Div Res & Dev, Dept Biochem Res & Drug Design, Cesta Brdo 49, Ljubljana, Slovenia KRKA DD Cesta Brdo 49 Ljubljana Slovenia Ljubljana, Slovenia
Citazione:
N. Cimerman et al., "Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients", CLIN CHIM A, 300(1-2), 2000, pp. 83-95

Abstract

The effect of asthma pathogenesis on serum cystatin C, a potent inhibitor of cysteine proteinases and a newly proposed marker of the renal function, has not been yet determined. The objectives were to determine the 24-h pattern of cystatin C and creatinine concentrations in sera of asthmatic patients in order to test whether their concentrations might reflect circadian rhythms, the disease severity and the effect of therapy. Serum concentrationsof cystatin C and creatinine were determined in steroid-independent and steroid-dependent asthmatics before and after 1 week of treatment with methylprednisolone and cyclosporin A, respectively. Samples were collected every 4 h during a 24-h period. Little or no significant effects of time on cystatin C and creatinine concentrations over a 24-h period were observed in healthy and asthmatic sera. However, significantly higher cystatin C concentrations were found in asthmatic patients compared to controls which suggests its role in the pathogenesis of asthma. Methylprednisolone increased and cyclosporin A decreased serum cystatin C concentrations after 1 week of therapy. Additionally these results support the need for the evaluation of cystatin C as a marker of glomerular filtration rate determination in asthma, (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:39:10