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Titolo:
Bioartificial cartilage
Autore:
Rudert, M; Hirschmann, F; Schulze, M; Wirth, CJ;
Indirizzi:
Hannover Med Sch, Dept Orthopaed, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 aed, D-30625 Hannover, Germany
Titolo Testata:
CELLS TISSUES ORGANS
fascicolo: 2-3, volume: 167, anno: 2000,
pagine: 95 - 105
SICI:
1422-6405(2000)167:2-3<95:BC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIODEGRADABLE POLYMER SCAFFOLDS; ARTICULAR-CARTILAGE; ALLOGRAFT CHONDROCYTES; PROTEOGLYCAN SYNTHESIS; PERFUSION CULTURE; MATRIX SYNTHESIS; FIBRIN MATRIX; CELL-SHAPE; TISSUE; COLLAGEN;
Keywords:
cartilage repair; osteochondral defects; chondrocytes; cell culture; tissue engineering; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Rudert, M Hannover Med Sch, Dept Orthopaed, Heimchenstr 1-7, D-30625 Hannover, Germany Hannover Med Sch Heimchenstr 1-7 Hannover Germany D-30625 rmany
Citazione:
M. Rudert et al., "Bioartificial cartilage", CELLS T ORG, 167(2-3), 2000, pp. 95-105

Abstract

Cartilage is a highly differentiated tissue. Its three-dimensional composition of cells and matrix is able to resist intensive mechanical loads. The capacity of cartilage tissue for regeneration is limited. Chondrocytes are responsible for matrix production of cartilage tissue. Enzymatic isolation and expansion of chondrocytes with cell culture techniques has been improved in the last years. These cells can be cultured on different three-dimensional culture systems suitable for transplantation to repair localized cartilage defects. Two types of bioresorbable polymer fleece matrices (PLLA and a composite fleece of polydioxanone and polyglactin) and lyophilized dura as a biological carrier are tested. Phenotypic and morphological appearance of the cultured articular rabbit chondrocytes is preserved on all three types of transport media. Production of glycosaminoglycans has been shown by Alcian blue staining, production of collagen by azan staining. Chondroitin 4- and 6-sulfate are detected immunohistochemically in the created constructs. The different carriers have specific characteristics regarding their suitability for the creation of bioartificial cartilage. This tissue is transplantable into articular cartilage defects and could, therefore, improve theminor intrinsic healing capacity of cartilage tissue. Copyright (C) 2000 S. Karger AG,Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:31:16