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Titolo:
Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization
Autore:
Muscheck, M; Abol-Enein, H; Chew, K; Moore, D; Bhargava, V; Ghoneim, MA; Carroll, PR; Waldman, FM;
Indirizzi:
Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA Univ CalifSan Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Mansoura, Urol & Nephrol Ctr, Mansoura 35516, Egypt Univ Mansoura Mansoura Egypt 35516 & Nephrol Ctr, Mansoura 35516, Egypt VA Med Ctr, Dept Pathol, San Francisco, CA USA VA Med Ctr San Francisco CA USA Ctr, Dept Pathol, San Francisco, CA USA Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
CARCINOGENESIS
fascicolo: 9, volume: 21, anno: 2000,
pagine: 1721 - 1726
SICI:
0143-3334(200009)21:9<1721:COGCIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE COPY NUMBER; CELL CARCINOMA; URINARY-BLADDER; CHROMOSOMAL IMBALANCES; HOMOZYGOUS DELETIONS; SOLID TUMORS; P53 GENE; EXPRESSION; PROGRESSION; ABERRATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Waldman, FM Univ Calif San Francisco, Ctr Canc, Box 0808, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0808 San Francisco CA USA 94143 A
Citazione:
M. Muscheck et al., "Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization", CARCINOGENE, 21(9), 2000, pp. 1721-1726

Abstract

The development of bladder tumors has been associated with a number of causative agents, including schistosomiasis. Schistosome-related cancers show different clinical and pathological features compared with non-schistosome-related bladder cancers, occurring in younger patients, and being predominantly of squamous cell type. This study addresses the difference between squamous and transitional tumor types in the presence of schistosome infectionas a measure of the relationship between tumor genotype and phenotype, We have used comparative genomic hybridization to analyze primary muscle-invasive schistosome-related bladder tumors in 54 patients. Twenty-six of these tumors were squamous cell carcinomas; the remaining 28 were of transitionalcell type. On average, transitional cell tumors showed 1.8 times the number of chromosomal aberrations as squamous cell tumors (14.4 versus 8.2, P < 0.001). For both groups combined, the most prevalent genetic alterations were losses of 8p and 18q, and gains of 8q, Transitional cell cancers also showed frequent losses involving 5q, 9p, 10q, 11p and 11q, and gains at 1q and 17q. Loss of 11p was significantly more frequent in TCC than in SCC tumors (50 versus 4%, P = 0.01). Squamous cell cancers showed more frequent losses of 17p and 18p than transitional tumors, which was clearly significant given the overall reduced frequency of changes in squamous cancers (P = 0.001 and P = 0.03, respectively). These data show that different histologic subgroups of bladder tumors are characterized by distinct patterns of chromosomal alterations. The genetic changes found in the transitional cell group are similar to those reported in non-schistosome-related transitional cell tumors, but differ from tumors exhibiting squamous differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:03:24