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Titolo:
Spasmolytic effects of prostaglandin E-1 on serotonin-induced bronchoconstriction and pulmonary hypertension in dogs
Autore:
Hashimoto, Y; Hirota, K; Yoshioka, H; Hashiba, E; Kudo, T; Ishihara, H; Matsuki, A;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan
Titolo Testata:
BRITISH JOURNAL OF ANAESTHESIA
fascicolo: 3, volume: 85, anno: 2000,
pagine: 460 - 462
SICI:
0007-0912(200009)85:3<460:SEOPEO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Keywords:
airway, resistance; lung, bronchus; lung, respiratory resistance; equipment, bronchoscope; serotonin (5-hydroxytryptamine);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Hirota, K Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 mori 0368562, Japan
Citazione:
Y. Hashimoto et al., "Spasmolytic effects of prostaglandin E-1 on serotonin-induced bronchoconstriction and pulmonary hypertension in dogs", BR J ANAEST, 85(3), 2000, pp. 460-462

Abstract

In this study, we simultaneously evaluated the spasmolytic effects of prostaglandin E-1 (PGE(1)) on serotonin-induced bronchoconstriction and pulmonary hypertension. Eleven mongrel dogs (8 - 12 kg) anaesthetized with pentobarbital were assigned to two groups: saline (n = 4) and PGE(1) (n = 7). Bronchoconstriction and pulmonary hypertension were elicited with serotonin 10 mu g kg(-1) + 1 mg kg(-1) h(-1) and assessed as the percentage change in bronchial cross-sectional area (BCA) measured by bronchoscopy and pulmonary vascular resistance (PVR), respectively. Thirty minutes after starting the serotonin infusion, saline or PGE(1) 0 (saline), 0.01, 0.1, 1.0 or 10 mu g kg(-1) i.v. was given. %BCA and %PVR (basal = 100%) were assessed before and30 min after serotonin, and 30 and 60 min after saline (saline group) or 5min after each dose of PGE(1) (PGE(1) group). In the saline group, pulmonary hypertension and bronchoconstriction were stable. In the PGE(1) group, PGE(1) at greater than or equal to 0.1 mu g kg(-1) significantly decreased %BCA and 10 mu g kg(-1) almost fully reversed the constriction (from mean (SEM) 56.2% (4.9%) to 94.4% (3.7%)). %PVR was significantly decreased at 10 mu g kg(-1) (from 230% (24%) to 176% (11%)) only. We suggest that PGE(1) mayproduce bronchodilation rather than pulmonary vasodilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 15:42:52