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Titolo:
Selective neuronal vulnerability during experimental scrapie infection: Insights from an ultrastructural investigation
Autore:
Bouzamondo, E; Milroy, AM; Ralston, HJ; Prusiner, SB; DeArmond, SJ;
Indirizzi:
Univ Calif San Francisco, Dept Neurol, Neuropathol Unit, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Inst Neurodegenerat Dis, San Francisco, CA 94143USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA 94143USA Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, WM Keck Fdn, Ctr Integrat Neurosci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 874, anno: 2000,
pagine: 210 - 215
SICI:
0006-8993(20000825)874:2<210:SNVDES>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB-DISEASE; DARK NEURONS; PRION DISEASES; HAMSTER BRAIN; RAT; DAMAGE; APPEARANCE;
Keywords:
prion (PrPc); neuronal degeneration; Syrian hamster; GABA; shrunken dark neuron; electron microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: DeArmond, SJ Univ Calif San Francisco, Dept Neurol, Neuropathol Unit, 513 Parnassus Ave,HSW 430,Box 0506, San Francisco, CA 94143 USA Univ Calif San Francisco 513 Parnassus Ave,HSW 430,Box 0506 San Francisco CA USA 94143
Citazione:
E. Bouzamondo et al., "Selective neuronal vulnerability during experimental scrapie infection: Insights from an ultrastructural investigation", BRAIN RES, 874(2), 2000, pp. 210-215

Abstract

The goal was to test whether all neurons are equally susceptible to degeneration in response to PrPSc scrapie infection. We tested this by immunogoldGABA labeling. Our ultrastructural results indicates that GABAergic neurons are less vulnerable than other neuronal populations. This conclusion is supported by our findings: (1) reversal of the normal ratio of non-GABAegic to GABAergic neurons in the terminal stages, which implies that non-GABAergic neurons degenerated earlier, and (2) that the degeneration of GABAergic neurons occurs late in the disease after reactive astrogliosis, a response to nerve cell death. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:11:14