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Titolo:
Stereoelectroencephalography in focal cortical dysplasia - A 3D approach to delineating the dysplastic cortex
Autore:
Chassoux, F; Devaux, B; Landre, E; Turak, B; Nataf, F; Varlet, P; Chodkiewicz, JP; Daumas-Duport, C;
Indirizzi:
Ctr Hosp St Anne, Serv Neurochirurg, Dept Neurosurg, F-75014 Paris, FranceCtr Hosp St Anne Paris France F-75014 t Neurosurg, F-75014 Paris, France Ctr Hosp St Anne, Dept Neuropathol, F-75014 Paris, France Ctr Hosp St Anne Paris France F-75014 Neuropathol, F-75014 Paris, France
Titolo Testata:
BRAIN
, volume: 123, anno: 2000,
parte:, 8
pagine: 1733 - 1751
SICI:
0006-8950(200008)123:<1733:SIFCD->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL MIGRATION DISORDERS; EPILEPSIA PARTIALIS CONTINUA; INTRACTABLE PARTIAL EPILEPSY; SURGICAL-TREATMENT; INFANTILE SPASMS; CEREBRAL-CORTEX; EEG FINDINGS; DYSGENESIS; ABNORMALITIES; CHILDREN;
Keywords:
cortical dysgenesis; epilepsy surgery; EEG; intracranial recordings; neuropathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Chassoux, F Ctr Hosp St Anne, Serv Neurochirurg, Dept Neurosurg, 1 Rue Cabanis, F-75014 Paris, France Ctr Hosp St Anne 1 Rue Cabanis Paris France F-75014 s, France
Citazione:
F. Chassoux et al., "Stereoelectroencephalography in focal cortical dysplasia - A 3D approach to delineating the dysplastic cortex", BRAIN, 123, 2000, pp. 1733-1751

Abstract

Focal cortical dysplasia (FCD) is an increasingly recognized cause of intractable epilepsy, Surgical data suggest that the dysplastic cortex should be removed to obtain freedom from seizures, but the prognosis remains poor as FCD is difficult to delineate by imaging, We retrospectively analysed a series of 28 patients (aged 5-41 years, median 16.5 years) with FCD who had been investigated by stereoelectroencephalography (SEEG) between 1964 and 1995, Neurophysiological data were correlated with histological findings andsurgical outcome, MRI was available for only seven patients, Severe partial epilepsy of early onset, pre-existing neurological deficit (68%) and cognitive impairment were the main clinical features, FCD was distributed equally between all lobes except for the temporal lobe, and was found predominantly on the mesial aspect of the cerebral hemispheres, SEEG findings provided evidence of dysplastic tissue epileptogenicity, as demonstrated by intralesional rhythmic spike discharges, the onset of ictal discharges and a low epileptogenic threshold, The epileptogenic zone corresponded to histologically defined FCD in 82% of the cases, Despite the lack of adequate neuroimaging in most cases, 64% of the patients became seizure-free after surgery, The main predictors of a favourable outcome were complete removal of the epileptogenic zone (P < 0.01) and complete removal of the dysplastic cortex (P< 0.01). These results emphasize the usefulness of neurophysiological datain accurately assessing the extent of the FCD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:51:30