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Titolo:
Donor leukocyte infusions in acute lymphocytic leukemia
Autore:
Collins, RH; Goldstein, S; Giralt, S; Levine, J; Porter, D; Drobyski, W; Barrett, J; Johnson, M; Kirk, A; Horowitz, M; Parker, P;
Indirizzi:
Univ Texas, SW Med Ctr, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 iv Texas, SW Med Ctr, Dallas, TX 75390 USA Baylor Sammons Canc Ctr, Dallas, TX USA Baylor Sammons Canc Ctr Dallas TXUSA r Sammons Canc Ctr, Dallas, TX USA H Lee Moffit Canc Ctr & Res Inst, Tampa, FL USA H Lee Moffit Canc Ctr & Res Inst Tampa FL USA & Res Inst, Tampa, FL USA Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Anderson Canc Ctr, Houston, TX 77030 USA Univ Michigan, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Michigan, Ann Arbor, MI 48109 USA Univ Penn, Sch Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 , Sch Med, Philadelphia, PA 19104 USA Med Coll Wisconsin, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 consin, Milwaukee, WI 53226 USA NHLBI, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892NHLBI, Bethesda, MD 20892 USA Med Coll Wisconsin, Int Bone Marrow Transplant Registry, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 gistry, Milwaukee, WI 53226 USA
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 5, volume: 26, anno: 2000,
pagine: 511 - 516
SICI:
0268-3369(200009)26:5<511:DLIIAL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; VERSUS-HOST DISEASE; EXTRAMEDULLARY RELAPSE; COMPLETE REMISSION; CHRONIC GRAFT; TRANSFUSIONS; CELLS;
Keywords:
acute lymphocytic leukemia; donor leukocyte infusions; adoptive immunotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Collins, RH Univ Texas, SW Med Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
R.H. Collins et al., "Donor leukocyte infusions in acute lymphocytic leukemia", BONE MAR TR, 26(5), 2000, pp. 511-516

Abstract

Donor leukocyte infusion (DLI) has well-documented activity in CML but therole of DLI in other diseases is less well defined, To evaluate the strategy in acute lymphocytic leukemia (ALL) we evaluated 44 ALL patients from 27centers who were treated with DLI, Patients with persistent or recurrent disease received DLI from the original marrow donor (30 matched related, four mismatched family, and 10 matched unrelated). Chemotherapy was given before DLI to 28 patients. Of 15 patients who received no pre-DLI chemotherapy,two achieved complete remissions, lasting 1112 and 764+ days. In four patients who received DLI as consolidation of remission induced by chemotherapyor immunosuppression-withdrawal, duration of remission post DI,I was 65, 99, 195 and 672+ days. Of 25 patients who received DLI in the nadir after chemotherapy, 13 survived greater than or equal to 30 days post DLI but did not achieve remission, seven died within less than 30 days post DLI, and five entered remissions that lasted 42, 68, 83, 90, 193 days. Seven patients who did not respond to the initial DLI received a second DLI; none of these patients attained durable remission, Eighteen of 37 evaluable patients developed acute GVHD and five of 20 evaluable patients developed chronic GVHD. Overall actuarial survival is 13% at 3 years. In conclusion, DLI has limited benefit in ALL. New approaches are needed in this group of patients.

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Documento generato il 28/09/20 alle ore 17:35:08