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Titolo:
When injected into the fimbria-fornix/cingular bundle, not in the raphe, 5,7-dihydroxytryptamine prevents amphetamine-induced hyperlocomotion
Autore:
Lehmann, O; Jeltsch, H; Bertrand, F; Lazarus, C; Will, B; Cassel, JC;
Indirizzi:
Univ Strasbourg 1, CNRS, Lab Neurosci Comportementales & Cognit, UMR 7521,F-67000 Strasbourg, France Univ Strasbourg 1 Strasbourg France F-67000 1,F-67000 Strasbourg, France
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 114, anno: 2000,
pagine: 213 - 217
SICI:
0166-4328(200009)114:1-2<213:WIITFB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; MEDIAL PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; RAT; LESIONS; INVOLVEMENT; FORNIX; HIPPOCAMPUS; MODULATION;
Keywords:
amphetamine; cingular bundle; 5,7-dihydroxptryptamine; dopamine; fimbria-fornix; hippocampus; locomotor activity; raphe; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Cassel, JC Univ Strasbourg 1, CNRS, Lab Neurosci Comportementales & Cognit, UMR 7521,12 Rue Goethe, F-67000 Strasbourg, France Univ Strasbourg 1 12 Rue Goethe Strasbourg France F-67000 ance
Citazione:
O. Lehmann et al., "When injected into the fimbria-fornix/cingular bundle, not in the raphe, 5,7-dihydroxytryptamine prevents amphetamine-induced hyperlocomotion", BEH BRA RES, 114(1-2), 2000, pp. 213-217

Abstract

The locomotor effects of acute amphetamine treatment (1 mg/kg, i.p.) were assessed in Long-Evans rats after 5,7-dihydroxytryptamine (5,7-DHT) injections into the fimbria-fornix/cingular bundle (FiFx/CB; 4 mu g/side), or the dorsal and median raphe (Raphe; 10 mu g). In control rats, amphetamine induced a significant increase of home-cage activity for about 2 h. This effectwas similar in Raphe rats, but was absent in FiFx/CB rats. The raphe lesions reduced serotonin concentrations by 50% in the dorsal hippocampus, 75% in the ventral hippocampus and 58% in the fronto-parietal cortex. After FiFx/CB lesions, the reduction amounted 50, 61 and only 25%, in each of these regions, respectively. In the fronto-partietal cortex, dopamine concentration was significantly decreased in Raphe (- 27%) and FiFx/CB rats (- 65%). The results suggest that a serotonergic denervation of the hippocampus by injections of 5,7-DHT into the FiFx/CB pathways hampers the stimulating effects of amphetamine on locomotor activity. This effect might be related to thereduced dopaminergic tone in the fronto-parietal cortex. (C) 2000 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:44:17