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Titolo:
Ethological confirmatory factor analysis of anxiety-like behaviour in the murine elevated plus-maze
Autore:
Wall, PM; Messier, C;
Indirizzi:
Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada Univ Ottawa Ottawa ON Canada K1N 6N5 Psychol, Ottawa, ON K1N 6N5, Canada
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 114, anno: 2000,
pagine: 199 - 212
SICI:
0166-4328(200009)114:1-2<199:ECFAOA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON FACTOR-ANALYSIS; ANIMAL-MODELS; ETHOPHARMACOLOGICAL ANALYSIS; SPECIFICATION SEARCHES; RECEPTOR ANTAGONIST; COMPONENT ANALYSIS; MICE; MOUSE; RAT; EXPERIENCE;
Keywords:
confirmatory factor analysis; anxiety; elevated plus-maze; model hypothesis testing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Wall, PM Univ Ottawa, Sch Psychol, Vanier Room 202, Ottawa, ON K1N 6N5, Canada Univ Ottawa Vanier Room 202 Ottawa ON Canada K1N 6N5 6N5, Canada
Citazione:
P.M. Wall e C. Messier, "Ethological confirmatory factor analysis of anxiety-like behaviour in the murine elevated plus-maze", BEH BRA RES, 114(1-2), 2000, pp. 199-212

Abstract

The elevated plus-maze has been used in animal research to measure anxietysince 1985 and is currently the most widely used animal model of anxiety. Since this paradigm has been the subject of several principal components analyses, it is well qualified for confirmatory factor analysis research. Thecurrent report builds on the substantial theoretical knowledge and empirical data obtained from these structural analyses with a view to obtain further progress in the evolution of our understanding of animal anxiety in the elevated plus-maze. The purpose of the present report was two-fold: (a) to test if the a piori imposition of a 3-factor model, or a competing 2-factorelevated plus-maze model, would fit our sample (n = 200 CD-1 mice) data ineach of two trials within an inferential confirmatory factor analytic framework; (b) provide a well-fitting model that confers indicator variables that can most effectively and parsimoniously measure underlying constructs ofelevated plus-maze behaviour. Multiple model-fitting criteria were used, and issues related to data non-normality, outliers, replicability of the model, sampling error and error of approximation ill the estimation of final model fit were addressed. The final 2-factor model, with estimated error covariance between two different pairs of indicator variables, was a good fit on the trial-1 data, although it was necessary to allow unprotected stretchattends to non-significantly cross-load on factor-2. A 2-factor model alsofit the trial-2 data from the present analysis, although it was necessary to allow closed arm time ratio to negatively cross-load on factor-1. These results indicate that inferential hypothesis testing and model building procedures within a confirmatory factor analysis framework produces interpretable animal anxiety indices in the elevated plus-maze. Moreover, a 2-factor,rather than a 3-factor model, parsimoniously and unambiguously explained the underlying constructs of anxiety-like mouse behaviour in the elevated plus-maze in the present study. Taken together, a reduction in the growing number of behavioural indices reported in elevated plus-maze pharmacological studies is suggested. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/11/20 alle ore 14:35:17