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Titolo:
The antinociceptive effect of trazodone in mice is mediated through both mu-opioid and serotonergic mechanisms
Autore:
Schreiber, S; Backer, MM; Herman, I; Shamir, D; Boniel, T; Pick, CG;
Indirizzi:
Chaim Sheba Med Ctr, Dept Psychiat C, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Tel Aviv Univ, Sackler Sch Med, Dept Anat & Anthropol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 hropol, IL-69978 Tel Aviv, Israel Jaffa Ctr Treatment Drug Dependent Patients, Tel Aviv, Israel Jaffa Ctr Treatment Drug Dependent Patients Tel Aviv Israel viv, Israel Chaim Sheba Med Ctr, Pharmaceut Serv, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1-2, volume: 114, anno: 2000,
pagine: 51 - 56
SICI:
0166-4328(200009)114:1-2<51:TAEOTI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT DRUGS; ANALGESIA; MORPHINE; RAT; RECEPTOR;
Keywords:
antidepressants; antinociception; hotplate; opioid receptor subtypes; pain; serotonin; trazodone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schreiber, S Chaim Sheba Med Ctr, Dept Psychiat C, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 er, Israel
Citazione:
S. Schreiber et al., "The antinociceptive effect of trazodone in mice is mediated through both mu-opioid and serotonergic mechanisms", BEH BRA RES, 114(1-2), 2000, pp. 51-56

Abstract

The antinociceptive effects of trazodone (a triazolopyridine derivative with antidepressant activity) and its interaction with various opioid, noradrenaline and serotonin receptor subtypes were evaluated. Mice were tested with a hotplate analgesia meter. Trazodone induced a dose-dependent antinociceptive effect following i.p. administration. The ED50 for mice in the hotplate assay for trazodone was 24.8 mg/kg (9.8; 67.4; 95% CL). The effect of opioid, adrenergic and serotonergic receptor antagonists was examined as to their ability to block trazodone antinociception. Trazodone-induced antinociception was significantly inhibited by naloxone, beta-FNA acid naloxonazine, but not by nor-BNI or naltrindole, implying involvement of mu 1- and mu 2-opioid mechanisms. When adrenergic and serotonergic antagonists were used, metergoline (p < 0.05) but not phentolamine or yohimbine, decreased antinociception elicited by trazodone, implying a clear 5-HT mechanism of antinociception. When trazodone was administered together with various agonists of the opioid receptor subtypes, it significantly potentiated antinociception mediated by mu 1- and mu 2-opioid receptor subtypes. Summing up these results, we conclude that the antinociceptive effect of trazodone is mainly influenced by the mu 1- + mu 2-opioid receptor subtype combined with the serotonergic receptor. These results explain the diffuse clinical use of trazodone in the management of some pain syndromes, and in opioid- and alcohol-detoxification programs, but raise questions regarding a possible 'indirect' opioid-dependence induced by trazodone itself. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:04:41