Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Compensatory vasoconstrictor effects of sodium pentobarbital on the hindquarters of conscious normotensive control and lumbar-sympathectomized Wistarrats
Autore:
Teranishi, Y; Tsuru, H; Shimomura, H; Amano, T; Matsubayashi, H;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Physiol, Minami Ku, Hiroshima 7348551, JapanHiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Toho Univ, Sch Med, Dept Pharmacol, Ohta Ku, Tokyo 1438540, Japan Toho Univ Tokyo Japan 1438540 t Pharmacol, Ohta Ku, Tokyo 1438540, Japan Hiroshima Univ, Sch Med, Res Facil Lab Anim Sci, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Hiroshima Univ, Sch Med, Dept Pharmacol, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 3, volume: 82, anno: 2000,
pagine: 130 - 136
SICI:
1566-0702(20000814)82:3<130:CVEOSP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC-OUTPUT; ANESTHESIA; TONE;
Keywords:
hindquarter vascular beds; vasoconstrictor tone; pentobarbital anesthesia lumbar sympathectomy; compensation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Teranishi, Y Hiroshima Univ, Sch Med, Dept Physiol, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 shima 7348551, Japan
Citazione:
Y. Teranishi et al., "Compensatory vasoconstrictor effects of sodium pentobarbital on the hindquarters of conscious normotensive control and lumbar-sympathectomized Wistarrats", AUTON NEURO, 82(3), 2000, pp. 130-136

Abstract

The aim of this study was to compare the vasoconstrictor effect of sodium pentobarbital on the hindquarter resistance of intact control Wistar rats with the effect on lumbar-sympathectomized rats. For this purpose, mean arterial pressure (MAP) and hindquarter (supplied terminal aorta) flow (HQF) were simultaneously measured in these conscious rats with an arterial in dwelling cannula and electromagnetic Row probe implanted around the terminal aorta. Hindquarter resistance (HQR) was calculated as MAP divided by HQF. In the intact control conscious rats, subsequent pentobarbital anesthesia (30 mg/kg, i.v.) caused an increase in HQR (+43.5+/-7.4%, mean+/-S.E.M.) and a decrease in MAP (-17.0+/-3.2%). After pentobarbital anesthesia, subsequent ganglionic blockade with hexamethonium bromide (C6; 25 mg, i.v.) induced a significant decrease in HQR (-30.9+/-3.0%) with a further lowering of MAP (-20.9+/-1.6%). However, in rats not anesthetized with sodium pentobarbital,C6 alone induced almost no change in HQR (-3.4+/-5.3%), even when MAP was lowered (-24.2+/-2.5%). In the lumbar-sympathectomized rats, pentobarbital anesthesia produced almost no change in HQR (-11.7+/-4.4%), although MAP decreased significantly (-24.3+/-2.2%). These findings suggest that: (1) sodium pentobarbital anesthesia newly generates a compensatory vasoconstrictor tone in the hindquarters acting against the depressor effect, and (2) the vasocompensator tone is controlled by the efferent fibers, including those in the lumbar sympathetic nerves. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:09:36