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Titolo:
Mechanism of anemia associated with autonomic dysfunction in rats
Autore:
Obayashi, K; Ando, Y; Terazaki, H; Yamashita, T; Nakamura, M; Suga, M; Uchino, M; Ando, M;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Lab Med, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 pt Lab Med, Kumamoto 8600811, Japan Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 rnal Med 1, Kumamoto 8600811, Japan Kumamoto Univ, Sch Med, Dept Neurol, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 ept Neurol, Kumamoto 8600811, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 3, volume: 82, anno: 2000,
pagine: 123 - 129
SICI:
1566-0702(20000814)82:3<123:MOAAWA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL AMYLOIDOTIC POLYNEUROPATHY; RENAL-DISEASE; 6-HYDROXYDOPAMINE; ERYTHROPOIETIN; ERYTHROCYTOSIS;
Keywords:
anemia; autonomic dysfunction; 6-OHDA; erythropoietin; beta-adrenergic receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ando, Y Kumamoto Univ, Sch Med, Dept Lab Med, 1-1-1 Honjo, Kumamoto 8600811, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8600811 o 8600811, Japan
Citazione:
K. Obayashi et al., "Mechanism of anemia associated with autonomic dysfunction in rats", AUTON NEURO, 82(3), 2000, pp. 123-129

Abstract

The aim of this study was to elucidate the mechanism of anemia associated with autonomic dysfunction in rats. Using 6-hydroxydopamine (6-OHDA)-treated sympathectomized rats, changes in systolic blood pressure, plasma catecholamine levels, hemograms, erythropoietin (EPO) secretion, and beta-adrenergic receptors on erythrocytes were monitored, and compared with desipramine-and 6-OHDA-treated, and control rats. In 6-OHDA-treated rats, systolic blood pressure and plasma catecholamine levels significantly decreased from 7 days after 6-OHDA administration, returning to the control values on day 28. Hemoglobin (Hb), hematocrit (Hct) and red blood cell (RBC) levels significantly decreased from day 14 to day 28, and reached normal values after day35, but neither corpuscular constants nor white blood cell (WBC) levels changed after anemia occurred. Administration of desipramine 1 day before 6-OHDA injection prevented anemia. EPO levels did not elevate, even after bloodletting to load anemia, and the EPO circadian rhythm was irregular in 6-OHDA-treated rats. beta-adrenergic receptors measured using I-125-cyanopindolol (CYP) significantly decreased from day 7 to day 28, and reached normal values after day 35. These results suggest that irregular EPO secretion via disordered autonomic nerves may induce anemia in patients with autonomic disorders. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:04:40