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Titolo:
Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anaesthetised rats
Autore:
Edwards, E; Paton, JFR;
Indirizzi:
Univ Bristol, Sch Med Sci, Dept Physiol, Bristol B58 1TD, Avon, England Univ Bristol Bristol Avon England B58 1TD Bristol B58 1TD, Avon, England
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 3, volume: 82, anno: 2000,
pagine: 87 - 96
SICI:
1566-0702(20000814)82:3<87:GSORPA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; MEDULLARY RAPHE; 5-HT4 RECEPTORS; NEURONS DRIVEN; SUBSTANCE-P; PROJECTIONS; CONVERGENCE; RESPONSES; AFFERENTS; 5-HYDROXYTRYPTAMINE;
Keywords:
raphe pallidus; 5-HT4 receptors; phenylbiguanide; nucleus of the solitary tract;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Paton, JFR Univ Bristol, Sch Med Sci, Dept Physiol, Univ Walk, Bristol B581TD, Avon,England Univ Bristol Univ Walk Bristol Avon England B58 1TD von,England
Citazione:
E. Edwards e J.F.R. Paton, "Glutamate stimulation of raphe pallidus attenuates the cardiopulmonary reflex in anaesthetised rats", AUTON NEURO, 82(3), 2000, pp. 87-96

Abstract

Serotonin has been implicated as having a modulatory action on NTS neurones mediating vagal inputs controlling the cardiorespiratory system. Since raphe pallidus and raphe obscurus both send serotonergic projections to the NTS, we have investigated a neuromodulatory role for these structures on thecardiopulmonary reflex. A multibarrelled microelectrode positioned around the level of the area postrema was placed at varying depths into mid-line brainstem structures and the effect of glutamate stimulation on the cardiopulmonary reflex tested. Excitatory chemical stimulation in the region of raphe pallidus, but not raphe obscurus, attenuated significantly the respiratory and bradycardic components of the cardiopulmonary reflex. This attenuation was reversed by an NTS microinjection of RS-39604, a selective 5-HT4 receptor antagonist. We propose that neurones in raphe pallidus that project to the NTS can release serotonin which acts via 5-HT4 receptors to attenuatethe reflex phrenic nerve activity and heart rate components of the cardiopulmonary reflex. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:37:58