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Titolo:
Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect
Autore:
Weickert, TW; Goldberg, TE; Gold, JM; Bigelow, LB; Egan, MF; Weinberger, DR;
Indirizzi:
NIMH, Clin Brain Disorders Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 Disorders Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 9, volume: 57, anno: 2000,
pagine: 907 - 913
SICI:
0003-990X(200009)57:9<907:CIIPWS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOZYGOTIC TWINS DISCORDANT; ADULT READING TEST; RISK; DECLINE; IQ; INTELLIGENCE; PERFORMANCE; CHILDHOOD; DISORDERS; DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Goldberg, TE NIMH, Clin Brain Disorders Branch, NIH, MSC 1379,10 Ctr Dr, Bethesda, MD 20892 USA NIMH MSC 1379,10 Ctr Dr Bethesda MD USA 20892 a, MD 20892 USA
Citazione:
T.W. Weickert et al., "Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect", ARCH G PSYC, 57(9), 2000, pp. 907-913

Abstract

Background: Although intellectual and neurocognitive deficits accompany schizophrenia, there are inconsistencies in the literature concerning issues of intellectual decline, premorbid deficits, a modal deficit pattern, and preserved abilities. Methods: A battery of neuropsychological tests was administered once to 117 consecutively admitted patients with chronic schizophrenia and a group of27 healthy control subjects to examine patterns of premorbid and current intellect (measured by means of reading scores and IQ, respectively) and theattendant cognitive profiles in schizophrenia using classification methodsbased on clinically derived (IQ levels) and atheoretical (cluster) techniques. Results: Sixty patients (51%) with schizophrenia who displayed a general intellectual decline of 10 points or greater from estimated premorbid levelsalso exhibited deficits of executive function, memory, and attention. Twenty-eight patients (23%) with consistently low estimated premorbid intellectand current intellectual levels who displayed no evidence of IQ decline exhibited language and visual processing deficits in addition to deficits present in the intellectually declining group. The remaining 29 patients (25%)who displayed average estimated premorbid intellectual levels did not showIQ decline and exhibited a cognitive profile similar to normal, with the exception of executive function and attention impairment. Atheoretical analyses support the findings from clinically derived subgroups. Conclusions: These results suggest that IQ decline, although modal in schizophrenia, is not universally characteristic and that executive function and attention deficits may be core features of schizophrenia, independent of IQ variations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/02/20 alle ore 20:57:14