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Titolo:
Determination of salsolinol enantiomers by gas chromatography-mass spectrometry with cyclodextrin chiral columns
Autore:
Liu, YM; Gordon, P; Green, S; Sweedler, JV;
Indirizzi:
Jackson State Univ, Dept Chem, Jackson, MS 39110 USA Jackson State Univ Jackson MS USA 39110 Dept Chem, Jackson, MS 39110 USA Univ Illinois, Beckman Inst, Dept Chem, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 n Inst, Dept Chem, Urbana, IL 61801 USA
Titolo Testata:
ANALYTICA CHIMICA ACTA
fascicolo: 1, volume: 420, anno: 2000,
pagine: 81 - 88
SICI:
0003-2670(20000907)420:1<81:DOSEBG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARKINSONS-DISEASE; R-SALSOLINOL; S-SALSOLINOL; DOPAMINERGIC NEUROTOXIN; LIQUID-CHROMATOGRAPHY; BIOLOGICAL SAMPLES; N-METHYL(R)SALSOLINOL; ISOQUINOLINE; DERIVATIVES; PLASMA;
Keywords:
salsolinol; enantiomeric determination; gas chromatography mass spectrometry; cyclodextrin chiral GC columns;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Liu, YM Jackson State Univ, Dept Chem, 1400 Lynch St, Jackson, MS 39110 USA Jackson State Univ 1400 Lynch St Jackson MS USA 39110 MS 39110 USA
Citazione:
Y.M. Liu et al., "Determination of salsolinol enantiomers by gas chromatography-mass spectrometry with cyclodextrin chiral columns", ANALYT CHIM, 420(1), 2000, pp. 81-88

Abstract

A gas chromatographic-mass spectrometric method for enantiomeric determination of salsolinol (Sal), a dopaminergic neurotoxin precursor, is described, Sal enantiomers were resolved on a cyclodextrin capillary column after O-trimethylsilylation with N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA). Superior resolution was achieved on P-cyclodextrin columns as compared with alpha- or gamma-cyclodextrin columns. A detection limit of 100 pg in sample or 2.5 pg on-column for each enantiomer was observed. The method has been applied to the quantification of Sal enantiomers in food stuff and nerve tissue samples. Both (R)- and (S)-Sal were found at the 30 mu g/g level in dried banana chips, a food rich in Sal. The ratio of (R)- to (S)-Sal was close to the unity, i.e. Sal present in this sample was racemic. However, (R)-Sal was the predominant enantiomer in homogenates of the cerebral ganglion from the sea slug, Aplysia californica. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/07/20 alle ore 22:30:58