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Titolo:
Timing of onset of antidepressant response with fluoxetine treatment
Autore:
Nierenberg, AA; Farabaugh, AH; Alpert, JE; Gordon, J; Worthington, JJ; Rosenbaum, JF; Fava, M;
Indirizzi:
Massachusetts Gen Hosp, Depress & Clin Res Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 9, volume: 157, anno: 2000,
pagine: 1423 - 1428
SICI:
0002-953X(200009)157:9<1423:TOOOAR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR DEPRESSIVE DISORDER; TRUE DRUG RESPONSE; PATTERN-ANALYSIS; TRIALS; AMITRIPTYLINE; OUTPATIENTS; EFFICACY; PLACEBO; DESIPRAMINE; IMPROVEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nierenberg, AA Massachusetts Gen Hosp, Depress & Clin Res Program, WACC 812,15 Parkman St, Boston, MA 02114 USA Massachusetts Gen Hosp WACC 812,15 Parkman St Boston MA USA 02114
Citazione:
A.A. Nierenberg et al., "Timing of onset of antidepressant response with fluoxetine treatment", AM J PSYCHI, 157(9), 2000, pp. 1423-1428

Abstract

Objective: The purpose of this study was to assess the time until onset ofantidepressant response with fluoxetine treatment. Method: The authors evaluated 182 outpatients with major depression who had a sustained acute response to fluoxetine treatment. The Outpatients received 8 weeks of treatment with 20 mg/day of fluoxetine and were assessed biweekly with the 17-item Hamilton Depression Rating Scale. The onset of response was defined as a 30% decrease in score on the Hamilton depression scalethat persisted and led to a 50% decrease by week 8. The Kaplan-Meier product limit and Cox regression analysis were used to model the relationship between relevant variables and time until onset of response. Results: The authors found that at weeks 2, 4, and 6, the probabilities ofhaving an onset of response (for responders) were 55.5%, 24.7%, and 9.3%, respectively. The cumulative probabilities of onset of response at each time point were 55.5%, 80.2%, and 89.5%,Neither demographics nor clinical characteristics of depression predicted time until initial response. Conclusions: These data suggest that more than half of eventual respondersto fluoxetine treatment at 8 weeks start to respond by week 2; over 75% start to respond by week 4. Conversely, the lack of onset of response at 4-6 weeks was associated with about a 73%-88% chance that patients would not have an onset of response by 8 weeks.

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Documento generato il 11/08/20 alle ore 16:11:51