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Titolo:
Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease
Autore:
Hurenkamp, GJB; van der Ende, A; Grundmeijer, HGLM; Tytgat, GNJ; Van der Hulst, RWM;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Gen Practice, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Kennemer Gasthuis, Dept Gastroenterol, Haarlem, Netherlands Kennemer Gasthuis Haarlem Netherlands stroenterol, Haarlem, Netherlands
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 8, volume: 14, anno: 2000,
pagine: 1065 - 1070
SICI:
0269-2813(200008)14:8<1065:EHEO47>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
METRONIDAZOLE RESISTANCE; SHORT-TERM; FOLLOW-UP; CLARITHROMYCIN; OMEPRAZOLE; GASTRITIS; IMPACT; HP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Hurenkamp, GJB Univ Amsterdam, Acad Med Ctr, Dept Gen Practice, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 15 Amsterdam Netherlands NL-1105 AZ
Citazione:
G.J.B. Hurenkamp et al., "Equally high efficacy of 4, 7 and 10-day triple therapies to eradicate Helicobacter pylori infection in patients with ulcer disease", ALIM PHARM, 14(8), 2000, pp. 1065-1070

Abstract

Background: In patients with ulcer disease the optimal dose and duration of Helicobacter pylori treatment containing omeprazole (O), metronidazole (M) and clarithromycin (C) has yet to be established. The efficacy might be influenced by metronidazole- and clarithromycin-resistance. Aim: To study the effect of duration of OMC treatment on its efficacy and influence of metronidazole-resistance and clarithromycin-resistance on the optimal duration. Materials and methods: Ulcer patients (n = 76) were randomized to three double-blind treatments of 10 days: OMC 4 consisted of 4 days b.d. 20 mg omeprazole, 400 mg metronidazole and 250 mg clarithromycin switched over to 6 days b.d. 20 mg omeprazole and placebo antibiotics (n = 27); OMC 7 consistedof 7 days b.d, omeprazole 20 mg, metronidazole 400 mg and clarithromycin 250 mg and 3 days b.d. omeprazole 20 mg and placebo antibiotics (n=25); OMC 10 consisted of 10 days b.d. omeprazole 20 mg, metronidazole 400 mg and clarithromycin 250 mg (n = 24), H, pylori was assessed by biopsies for cultureand histology pre- and 4-6 weeks after OMC therapy. Metronidazole-resistance and clarithromycin-resistance were assessed by the E-test. Results: Intention-to-treat-eradication rates were: OMC 4, 96%; OMC 7, 92%; and OMC 10, 96% (N.S.). All of the three per protocol eradication rates were 100% (95% CT: 85.2-100). Of 75 isolates, 16 were metronidazole-resistant and one was clarithromycin-resistant. Conclusion: In H. pylori-positive ulcer patients, OMC 4 is highly efficacious and as effective as OMC 7 and OMC 10. No influence of metronidazole-resistance or clarithromycin-resistance was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:13:50