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Titolo:
Systemic hypothermia following spinal cord compression injury in the rat: an immunohistochemical study on MAP 2 with special reference to dendrite changes
Autore:
Yu, WR; Westergren, H; Farooque, M; Holtz, A; Olsson, Y;
Indirizzi:
Univ Uppsala Hosp, Dept Genet & Pathol, Neuropathol Lab, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 ol Lab, S-75185 Uppsala, Sweden Uppsala Univ, Dept Neurosci, Neurosurg Unit, Uppsala, Sweden Uppsala UnivUppsala Sweden t Neurosci, Neurosurg Unit, Uppsala, Sweden
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 5, volume: 100, anno: 2000,
pagine: 546 - 552
SICI:
0001-6322(200011)100:5<546:SHFSCC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE-ASSOCIATED PROTEIN-2; TRAUMATIC BRAIN INJURY; SENSITIVE MARKER; NERVOUS-SYSTEM; BLOOD-FLOW; PEROXIDASE; TEMPERATURE; ISCHEMIA;
Keywords:
hypothermia; immunohistochemistry; microtubule-associated protein 2 (MAP2); rat; spinal cord injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, WR Univ Uppsala Hosp, Dept Genet & Pathol, Neuropathol Lab, S-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75185 S-75185 Uppsala, Sweden
Citazione:
W.R. Yu et al., "Systemic hypothermia following spinal cord compression injury in the rat: an immunohistochemical study on MAP 2 with special reference to dendrite changes", ACT NEUROP, 100(5), 2000, pp. 546-552

Abstract

Systemic hypothermia has been shown to exert neuroprotective effects in experimental ischemic CNS models caused by vascular occlusions. The present study addresses the question as to whether systemic hypothermia has similar neuroprotective qualities following severe spinal cord compression trauma using microtubule-associated protein 2 (MAP2) immunohistochemistry combined with the avidin-biotin-peroxidase complex method as marker to identify neuronal and dendritic lesions. Fifteen rats were randomized into three equallysized groups. One group sustained thoracic laminectomy. the others severe spinal cord compression trauma of the T8-9 segment. The control roup contained laminectomized animals submitted to a hypothermic procedure in which the esophageal temperature was reduced from 38 degrees C to 30 degrees C. Thetwo trauma groups were either submitted to the same hypothermic procedure or kept normothermic during the corresponding time. All animals were sacrificed 24 h following the surgical procedure. The MAP2 immunostaining in the normothermic trauma group indicated marked reductions in MAP2 antigen in the cranial and caudal peri-injury zones (T7 and T10, respectively). This reduction was much less pronounced in the hypothermic trauma group. In fact, the MAP2 antigen was present in almost equally sized areas in both the hypothermic groups independent of previous laminectomy alone or the addition of trauma. Our study thus indicates that hypothermia has a neuroprotective effect on dendrites of rat spinal cords subjected to compression trauma.

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Documento generato il 07/07/20 alle ore 22:17:18