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Titolo:
The N-methyl-D-aspartate-receptor antagonist dextromethorphan lacks analgesic effect in a human experimental ischemic pain model
Autore:
Plesan, A; Sollevi, A; Segerdahl, M;
Indirizzi:
Huddinge Univ Hosp, Dept Anaesthesia & Intens Care, Karolinska Inst, SE-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden SE-14186 t, SE-14186 Huddinge, Sweden Huddinge Univ Hosp, Div Clin Neurophysiol, Dept Med Lab Sci & Technol, Karolinska Inst, SE-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden SE-14186 t, SE-14186 Huddinge, Sweden
Titolo Testata:
ACTA ANAESTHESIOLOGICA SCANDINAVICA
fascicolo: 8, volume: 44, anno: 2000,
pagine: 924 - 928
SICI:
0001-5172(200009)44:8<924:TNADLA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
REDUCES POSTOPERATIVE PAIN; ADDING KETAMINE; MORPHINE; CAPSAICIN; MK-801;
Keywords:
NMDA-receptor antagonist; acute ischemic pain; dextromethorphan; ketamine; tourniquet test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Segerdahl, M Huddinge Univ Hosp, Dept Anaesthesia & Intens Care, Karolinska Inst, SE-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden SE-14186 uddinge, Sweden
Citazione:
A. Plesan et al., "The N-methyl-D-aspartate-receptor antagonist dextromethorphan lacks analgesic effect in a human experimental ischemic pain model", ACT ANAE SC, 44(8), 2000, pp. 924-928

Abstract

Background: N-methyl-D-aspartate-receptor antagonists may be useful in pain management. The aim of this study was to evaluate dextromethorphan (DEX),a commonly used oral antitussive drug with NMDA-receptor antagonistic properties, in respect of its analgesic properties as single drug and co-administered with morphine (MO) on experimental ischemic pain. In addition, the analgesic effects of another clinically available NMDA-receptor antagonist, ketamine (KET) as well as of morphine (MO) were tested as active controls. Methods: Nineteen healthy volunteers were included in the study. Experimental ischemic pain was induced using the forearm tourniquet test. Placebo (PLAC), oral DEX (30 and 90 mg, respectively), KET (9 mu g kg(-1) min(-1) i.v.), MO (0.1 mg kg(-1) i.v.) and the DEX+MO and KET+MO combinations were evaluated during eight separate experiments. Development of ischemic pain was rated by visual analog scale (VAS) every minute over 30 min and ratings were summed as sum of pain scores (SPS). Results: DEX by itself did not influence SPS compared to PLAC. The DEX+MO co-administration did not enhance MO-induced analgesia. MO and KET reduced pain ratings by 27% and 39%, respectively. The KET+MO combination showed noenhancement of the analgesic effect in comparison with the respective drugs in monotherapy. Conclusion: DEX in clinical doses has no effect on the present acute ischemic pain model and does not influence MO-induced analgesia. Further studieson other pain modalities are needed in order to evaluate the potential useof DEX in pain treat ment.

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Documento generato il 04/04/20 alle ore 08:38:15