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Titolo:
Efficacy and safety of selamectin against gastrointestinal nematodes in cats presented as veterinary patients
Autore:
Six, RH; Sture, GH; Thomas, CA; Clemence, RG; Benchaoui, HA; Boy, MG; Watson, P; Smith, DG; Jernigan, AD; Rowan, TG;
Indirizzi:
Pfizer Inc, Div Cent Res, Anim Hlth Clin Affairs, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 im Hlth Clin Affairs, Groton, CT 06340 USA Pfizer Ltd, Div Cent Res, Anim Hlth Clin Affairs, Sandwich CT13 9NJ, Kent,England Pfizer Ltd Sandwich Kent England CT13 9NJ Sandwich CT13 9NJ, Kent,England
Titolo Testata:
VETERINARY PARASITOLOGY
fascicolo: 3-4, volume: 91, anno: 2000,
pagine: 321 - 331
SICI:
0304-4017(20000823)91:3-4<321:EASOSA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTHELMINTIC EFFICACY; PYRANTEL PAMOATE; DOGS; EPIDEMIOLOGY; PREVALENCE; INFECTIONS;
Keywords:
selamectin; avermectin; Revolution (TM); Stronghold (TM); Felis catus; Toxocara cati; Toxascaris leonina; Ancylostoma spp.; Uncinaria stenocephala; cat; roundworms; ascarids; hookworms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Six, RH Pfizer Inc, Div Cent Res, Anim Hlth Clin Affairs, Eastern Point Rd, Groton, CT 06340 USA Pfizer Inc Eastern Point Rd Groton CT USA 06340 oton, CT 06340 USA
Citazione:
R.H. Six et al., "Efficacy and safety of selamectin against gastrointestinal nematodes in cats presented as veterinary patients", VET PARASIT, 91(3-4), 2000, pp. 321-331

Abstract

A series of randomized, controlled, masked, field (veterinary patient) studies were conducted in the USA and Europe to evaluate the efficacy of selamectin, a novel macrocyclic lactone of the avermectin subclass, in the treatment of naturally acquired gastrointestinal nematode infections in cats. After confirmation of ascarid and/or hookworm infection, 298 cats of various ages and breeds were randomly assigned to treatment with selamectin (n=202)or an existing commercially approved positive-control product (n=96). Unitdoses of selamectin (providing a minimum dosage of 6 mg kg(-1)) were administered topically to the skin in a single spot at monthly intervals, Quantitative fecal examinations were performed on days 0 (before treatment), 30, and 60. In the selamectin-treated cats, fecal ascarid egg counts were reduced by 99.6 to 100% on day 30, and by 99.9 to 100% on day 60. Fecal hookwormegg counts were reduced by 98.3% on day 30, and by 100% on day 60 in the selamectin-treated cats. The positive-control products achieved reductions in egg counts of 96.5 to 100% (ascarids) and 98.9 to 99.9% (hookworms). These studies have shown that monthly topical administration of selamectin is safe and highly effective in the treatment of naturally acquired ascarid andhookworm infections in cats. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:11:12