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Titolo:
Efficacy of selamectin in the treatment and prevention of flea (Ctenocephalides felis felis) infestations on dogs and cats housed in simulated home environments
Autore:
Shanks, DJ; Rowan, TG; Jones, RL; Watson, P; Murphy, MG; Smith, DG; Jernigan, AD;
Indirizzi:
Pfizer Ltd, Div Cent Res, Anim Hlth Clin Affairs, Sandwich CT13 9NJ, Kent,England Pfizer Ltd Sandwich Kent England CT13 9NJ Sandwich CT13 9NJ, Kent,England RBK House, Athlone, County Westmeat, Ireland RBK House Athlone County Westmeat Ireland lone, County Westmeat, Ireland Pfizer Inc, Div Cent Res, Anim Hlth Clin Affairs, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 im Hlth Clin Affairs, Groton, CT 06340 USA
Titolo Testata:
VETERINARY PARASITOLOGY
fascicolo: 3-4, volume: 91, anno: 2000,
pagine: 213 - 222
SICI:
0304-4017(20000823)91:3-4<213:EOSITT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUFENURON; BIOLOGY;
Keywords:
avermectins; selamectin; Revolution (TM); Stronghold (TM); Ctenocephalides spp.; fleas; environmental; dogs; cats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Shanks, DJ Pfizer Ltd, Div Cent Res, Anim Hlth Clin Affairs, Sandwich CT139NJ, Kent,England Pfizer Ltd Sandwich Kent England CT13 9NJ 13 9NJ, Kent,England
Citazione:
D.J. Shanks et al., "Efficacy of selamectin in the treatment and prevention of flea (Ctenocephalides felis felis) infestations on dogs and cats housed in simulated home environments", VET PARASIT, 91(3-4), 2000, pp. 213-222

Abstract

The efficacy of selamectin, a novel avermectin, in protecting dogs and cats against experimentally induced environmental flea (Ctenocephalides felis felis) infestations, was evaluated in a series of controlled and masked studies. Purpose-bred shorthaired cats and Beagles were randomly allocated to treatment with either selamectin at a minimum dosage of 6 mg kg(-1) of bodyweight in the commercial formulation or the negative control treatment (vehicle only), and housed in controlled simulated home environments capable of supporting the flea life cycle. Day 0 was defined as the first day of treatment. Treatments were administered topically in a single spot on the skinat the base of the neck in front of the scapulae. In environmental challenge studies, which were designed to evaluate the efficacy of selamectin in the treatment and control of established flea infestations, dogs and cats were each infested with 100 fleas on days -28 and -21 and placed in carpeted rooms in order to establish high levels of active flea infestation prior today 0. Treatments were administered monthly for 3 months. Flea comb countswere performed on days 14, 29, 44, 59, 74, and 90. Reductions in geometricmean flea comb counts for selamectin, compared with vehicle, were >99% from day 14 onwards for dogs, and >92% on day 29 and >99% on days 44, 59, 74, and 90 for cats (P=0.0001). In prevention of environmental infestation studies, dogs and cats were placed in environments capable of supporting flea infestations and given monthly treatments for 2 months, commencing on day 0,Animals were infested with 100 fleas on days 1 and 7, and flea comb countswere performed on days 29, 44, and 60. Reductions in geometric mean flea comb counts for selamectin, compared with vehicle, were >99% on days 29, 44,and 60 (P=0.0001) for dogs and cats. Monthly administration of selamectin to dogs and cats housed in environments highly suited to completion of the flea life cycle was shown to be highly effective in the treatment and prevention of flea infestations, without the need far supplementary environmental control measures. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:20:28