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Titolo:
Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [F-18]fallypride in nonhuman primates
Autore:
Christian, BT; Narayanan, TK; Shi, BZ; Mukherjee, J;
Indirizzi:
Wright State Univ, Kettering Med Ctr, Dept Internal Med Nucl Med, Dayton, OH 45435 USA Wright State Univ Dayton OH USA 45435 Med Nucl Med, Dayton, OH 45435 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 38, anno: 2000,
pagine: 71 - 79
SICI:
0887-4476(200010)38:1<71:QOSAED>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN BRAIN; GRAPHICAL ANALYSIS; F-18 FALLYPRIDE; RAT-BRAIN; BINDING; RADIOLIGAND; IDENTIFICATION; SCHIZOPHRENIA; TRANSPORTERS;
Keywords:
[F-18]fallypride; extrastriatal dopamine D-2 receptors; distribution volume ratio; graphical analysis; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Christian, BT Kettering Med Ctr, Dept Nucl Med PET, 3535 So Bldg, Kettering, OH 45429 USA Kettering Med Ctr 3535 So Bldg Kettering OH USA 45429 29 USA
Citazione:
B.T. Christian et al., "Quantitation of striatal and extrastriatal D-2 dopamine receptors using PET imaging of [F-18]fallypride in nonhuman primates", SYNAPSE, 38(1), 2000, pp. 71-79

Abstract

[F-18]Fallypride is a highly selective, high-affinity dopamine D-2 receptor ligand. The high affinity, K-D = 30 pM, makes it a suitable candidate forvisualizing both striatal and extrastriatal binding in the brain. In this work, dynamic PET studies of two macaque monkeys were acquired along with arterial plasma samples. Compartmental analysis and Logan plots were used toanalyze the striatum, thalamus, frontal, and temporal cortices and to validate a reference region of analysis which yields a distribution volume ratio (DVR). The cerebellum was used as the reference region. The results indicate that all methods of analysis are in close agreement over all the analyzed regions in the brain. The average DVRs for the two monkeys was found to be: caudate = 26, putamen = 29, thalamus = 3.8, frontal ctx = 1.7, and temporal ctx = 1.7 on a high-resolution PET scanner. It was found that a scan time of 2 h is needed to accurately estimate the DVR for all regions of the brain. The striatal regions require the longest to linearize and are the most sensitive to variations in time average tissue-to-plasma efflux constant, (k) over bar(2). For the extrastriatal regions, the effect of the (k) over bar(2) term on DVR calculation is negligible. Repeatability measurements for all regions were found to be within 10% using the DVR parameter. Synapse 38:71-79, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:16:00