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Titolo:
GENE-THERAPY OF T-HELPER CELLS IN HIV-INFECTION - MATHEMATICAL-MODEL OF THE CRITERIA FOR CLINICAL EFFECT
Autore:
LUND O; LUND OS; GRAM G; NIELSEN SD; SCHONNING K; NIELSEN JO; HANSEN JES; MOSEKILDE E;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB DK-2650 HVIDOVRE DENMARK TECH UNIV DENMARK,DEPT PHYS DK-2800 LYNGBY DENMARK
Titolo Testata:
Bulletin of mathematical biology
fascicolo: 4, volume: 59, anno: 1997,
pagine: 725 - 745
SICI:
0092-8240(1997)59:4<725:GOTCIH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; IMMUNE-SYSTEM RETROVIRUS; LYMPHOCYTE LIFE-SPAN; INTRACELLULAR IMMUNIZATION; REVERSE-TRANSCRIPTASE; EXPRESSING ANTISENSE; POPULATION-DYNAMICS; BONE-MARROW; IN-VIVO; TYPE-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
O. Lund et al., "GENE-THERAPY OF T-HELPER CELLS IN HIV-INFECTION - MATHEMATICAL-MODEL OF THE CRITERIA FOR CLINICAL EFFECT", Bulletin of mathematical biology, 59(4), 1997, pp. 725-745

Abstract

The paper presents a mathematical analysis of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. The analysis indicates that for such a therapy to be successful, it must protect the transduced cells against HIV-induced death. The transduced cells will not survive as a population if the gene therapy only blocks the spread of virus from transduced cells that become infected. The analysis also suggests that the degree of protection against disease-related cell death provided by the gene therapy is more important than the fraction of cells that is initially transduced. If only a small fraction of the cells can be transduced, transduction of T helper cells and transduction of haematopoietic progenitor cells will result in the same steady-state level of transduced T helper cells. For gene therapy to be efficient against HIV infection, our analysis suggests that a 100% protection against viral escape must be obtained. The study also suggests that a gene therapy against HIV infection should be designed to give the transduced cells a partial but not necessarily total protection against HIV-induced cell death, and to avoid the production ofviral mutants insensitive to the gene therapy. (C) 1997 Society for Mathematical Biology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:24:41