Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE MAD-RELATED PROTEIN SMAD7 ASSOCIATES WITH THE TGF-BETA RECEPTOR AND FUNCTIONS AS AN ANTAGONIST OF TGF-BETA SIGNALING
Autore:
HAYASHI H; ABDOLLAH S; QIU YB; CAI JX; XU YY; GRINNELL BW; RICHARDSON MA; TOPPER JN; GIMBRONE MA; WRANA JL; FALB D;
Indirizzi:
HOSP SICK CHILDREN,PROGRAM DEV BIOL,555 UNIV AVE TORONTO ON M5G 1X8 CANADA HOSP SICK CHILDREN,DIV GASTROENTEROL TORONTO ON M5G 1X8 CANADA MILLENNIUM PHARMACEUT INC CAMBRIDGE MA 02139 LILLY RES LABS,DIV RES TECHNOL & PROT INDIANAPOLIS IN 46285 BRIGHAM & WOMENS HOSP,DEPT MED,DIV VASC RES BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT PATHOL,DIV CARDIOVASC BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115
Titolo Testata:
Cell
fascicolo: 7, volume: 89, anno: 1997,
pagine: 1165 - 1173
SICI:
0092-8674(1997)89:7<1165:TMPSAW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
H. Hayashi et al., "THE MAD-RELATED PROTEIN SMAD7 ASSOCIATES WITH THE TGF-BETA RECEPTOR AND FUNCTIONS AS AN ANTAGONIST OF TGF-BETA SIGNALING", Cell, 89(7), 1997, pp. 1165-1173

Abstract

TGF beta signaling is initiated when the type I receptor phosphorylates the MAD-related protein, Smad2, on C-terminal serine residues. Thisleads to Smad2 association with Smad4, translocation to the nucleus, and regulation of transcriptional responses. Here we demonstrate that Smad7 is an inhibitor of TGF beta signaling. Smad7 prevents TGF beta-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2. Smad7 interacts stably with the activated TGF beta type I receptor, thereby blocking the association, phosphorylation,and activation of Smad2. Furthermore, mutations in Smad7 that interfere with receptor binding disrupt its inhibitory activity. These studies thus define a novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGF beta family receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:22:55