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Titolo:
Immunohistochemical expression of neural tissue markers (neuron-specific enolase, glial fibrillary acidic protein, S100 protein) in ameloblastic fibrodentinoma: A comparative study with ameloblastic fibroma
Autore:
Takeda, Y; Sato, H; Satoh, M; Nakamura, S; Yamamoto, H;
Indirizzi:
Iwate Med Univ, Sch Dent, Dept Oral Pathol, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan Iwate Med Univ, Cent Clin Lab, Div Clin Pathol, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan Nihon Univ, Sch Dent, Dept Pathol, Matsudo, Chiba 271, Japan Nihon Univ Matsudo Chiba Japan 271 Dept Pathol, Matsudo, Chiba 271, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 8, volume: 50, anno: 2000,
pagine: 610 - 615
SICI:
1320-5463(200008)50:8<610:IEONTM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIXED ODONTOGENIC-TUMORS; INTERMEDIATE FILAMENTS; IMMATURE DENTINOMA; TOOTH DEVELOPMENT; LESIONS; TEETH; INTERRELATIONSHIP; ODONTOMAS; PATTERNS; KERATIN;
Keywords:
ameloblastic fibrodentinoma; ameloblastic fibroma; glial fibrillary acidic protein; neuron-specific enolase; S100 protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Takeda, Y Iwate Med Univ, Sch Dent, Dept Oral Pathol, 19-1 Uchimaru, Morioka, Iwate 0208505, Japan Iwate Med Univ 19-1 Uchimaru Morioka Iwate Japan 0208505 , Japan
Citazione:
Y. Takeda et al., "Immunohistochemical expression of neural tissue markers (neuron-specific enolase, glial fibrillary acidic protein, S100 protein) in ameloblastic fibrodentinoma: A comparative study with ameloblastic fibroma", PATHOL INT, 50(8), 2000, pp. 610-615

Abstract

Formalin-fixed paraffin-embedded sections of three cases of ameloblastic fibrodentinoma (AFD) were studied by the avidin-biotin-peroxidase complex method using antibodies against neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP) and S100 protein and the results were compared with those in ameloblastic fibroma (AF). A striking histopathological characteristic of AFD was the formation of abortive dentin with various degrees of maturation at the epithelial-mesenchymal tissue interface. Central cells ofenamel organ-like epithelia with various stages of abortive dentin induction in AFD were generally positive for NSE. Dental lamina-like epithelial cells also showed positive staining in some areas. No cells were positive forNSE in AF. Positive staining for GFAP was observed in the juxta-epithelialmesenchymal tissue of the formation stage of immature dentin with various numbers of entrapped cells in AFD, but GFAP staining was negative in other mesenchymal and epithelial tissues at other stages. In AF, no GFAP-positivecells were found. There were a few S100 protein-positive cells found in the foci of epithelial components in both AFD and AF. Mesenchymal cells showing a dendritic or spindle shape were positive for S100 protein in some areas of AFD and AF. Although such cells in the mesenchymal component of pigmented AFD were more numerous than in non-pigmented AFD and AF, their distribution pattern in the former condition was basically similar to that in the latter. Although the present results, obtained from conventional immunohistochemical procedures, do not directly reflect the expression of neural crest-derived cells in the dentinogenesis of AFD, such results do not disprove the possibility of the expression of neural proteins probably related to neural crest-derived cells in dentinogenesis under certain pathologic conditions in odontogenic mixed tumors. Such a phenomenon may also occur during dentinogenesis in other odontogenic mixed tumors and in normal tooth differentiation, but at an undetectable level.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:17:13