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Titolo:
Evidence of the synthesis of opioid receptor like 1 receptor in nociceptinergic neurons in rat brain suggests the existence of autoreceptor: a confocal double staining study
Autore:
Wang, YQ; Wang, JL; Zhu, CB; Cao, XD; Wu, GC;
Indirizzi:
Shanghai Med Univ, Dept Neurobiol, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 290, anno: 2000,
pagine: 193 - 196
SICI:
0304-3940(20000901)290:3<193:EOTSOO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA; ORPHANIN-FQ; TISSUE DISTRIBUTION; CHROMOSOMAL LOCALIZATION; INSITU HYBRIDIZATION; MOLECULAR-CLONING; INDUCED ANALGESIA; GENE FAMILY; COLCHICINE;
Keywords:
ORL1 receptor; mRNA; nociceptin; autoreceptor; rat brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, GC Shanghai Med Univ, Dept Neurobiol, State Key Lab Med Neurobiol, 138Yi XueYuan Rd, Shanghai 200032, Peoples R China Shanghai Med Univ 138 Yi Xue Yuan Rd Shanghai Peoples R China 200032
Citazione:
Y.Q. Wang et al., "Evidence of the synthesis of opioid receptor like 1 receptor in nociceptinergic neurons in rat brain suggests the existence of autoreceptor: a confocal double staining study", NEUROSCI L, 290(3), 2000, pp. 193-196

Abstract

Opioid receptor like 1 (ORL1) receptor is a novel mem ber of the opioid receptor family, wh ich was not bound by any of the typical opioid receptor ligands but bound by the recently discovered nociceptin (also termed orphanin FQ) with high affinity. By using double staining of fluorescent in situ hybridization and immunohistochemistry, we observed the expression of ORL1 receptor mRNA in nociceptin-like immunoreactive neurons in multiple areas inrat brain including the hippocampus, arcuate nucleus in the hypothalamus, ventralateral periaquiductal gray (PAG) and raphe nuclei in brain stem. Theexpression of ORL1 mRNA in nociceptinergic neurons suggests that these receptors mediate, at least in part, the presynaptic autoreceptor functions. Further anatomical and functional significance of the autoreceptor of nociceptinergic neurons remain to be elucidated. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:29:37